CCDC8 protein (Homo sapiens) - STRING network view

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Score

CCDC8

coiled-coil domain containing 8 (538 aa)

Predicted Functional Partners:

TP53

0.944

KAT5

0.913

MAPK14

0.911

OBSL1

0.905

FBXW8

0.680

KCTD21

0.607

KCTD5

0.577

KCTD2

0.543

SSH3

0.529

ANK1

0.509

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANK1	CCDC8	ENSP00000265709	ENSP00000303158	ankyrin 1, erythrocytic	coiled-coil domain containing 8	0.509
ANK1	KCTD21	ENSP00000265709	ENSP00000339340	ankyrin 1, erythrocytic	potassium channel tetramerisation domain containing 21	0.540
ANK1	KCTD5	ENSP00000265709	ENSP00000301738	ankyrin 1, erythrocytic	potassium channel tetramerisation domain containing 5; Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4	0.409
CCDC8	ANK1	ENSP00000303158	ENSP00000265709	coiled-coil domain containing 8	ankyrin 1, erythrocytic	0.509
CCDC8	FBXW8	ENSP00000303158	ENSP00000310686	coiled-coil domain containing 8	F-box and WD repeat domain containing 8; Substrate-recognition component of a SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. In complex with CUL7, mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain	0.680
CCDC8	KAT5	ENSP00000303158	ENSP00000340330	coiled-coil domain containing 8	K(lysine) acetyltransferase 5	0.913
CCDC8	KCTD2	ENSP00000303158	ENSP00000312814	coiled-coil domain containing 8	potassium channel tetramerisation domain containing 2	0.543
CCDC8	KCTD21	ENSP00000303158	ENSP00000339340	coiled-coil domain containing 8	potassium channel tetramerisation domain containing 21	0.607
CCDC8	KCTD5	ENSP00000303158	ENSP00000301738	coiled-coil domain containing 8	potassium channel tetramerisation domain containing 5; Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4	0.577
CCDC8	MAPK14	ENSP00000303158	ENSP00000229794	coiled-coil domain containing 8	mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...]	0.911
CCDC8	OBSL1	ENSP00000303158	ENSP00000385636	coiled-coil domain containing 8	obscurin-like 1; Regulates CUL7-FBXW8-containing ubiquitin ligase complex, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Localizes CUL7 to the Golgi apparatus in neurons	0.905
CCDC8	SSH3	ENSP00000303158	ENSP00000312081	coiled-coil domain containing 8	slingshot homolog 3 (Drosophila); Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity)	0.529
CCDC8	TP53	ENSP00000303158	ENSP00000269305	coiled-coil domain containing 8	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity)	0.944
FBXW8	CCDC8	ENSP00000310686	ENSP00000303158	F-box and WD repeat domain containing 8; Substrate-recognition component of a SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. In complex with CUL7, mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain	coiled-coil domain containing 8	0.680
FBXW8	OBSL1	ENSP00000310686	ENSP00000385636	F-box and WD repeat domain containing 8; Substrate-recognition component of a SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. In complex with CUL7, mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain	obscurin-like 1; Regulates CUL7-FBXW8-containing ubiquitin ligase complex, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Localizes CUL7 to the Golgi apparatus in neurons	0.742
FBXW8	TP53	ENSP00000310686	ENSP00000269305	F-box and WD repeat domain containing 8; Substrate-recognition component of a SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. In complex with CUL7, mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity)	0.886
KAT5	CCDC8	ENSP00000340330	ENSP00000303158	K(lysine) acetyltransferase 5	coiled-coil domain containing 8	0.913
KAT5	TP53	ENSP00000340330	ENSP00000269305	K(lysine) acetyltransferase 5	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity)	0.999
KCTD2	CCDC8	ENSP00000312814	ENSP00000303158	potassium channel tetramerisation domain containing 2	coiled-coil domain containing 8	0.543
KCTD21	ANK1	ENSP00000339340	ENSP00000265709	potassium channel tetramerisation domain containing 21	ankyrin 1, erythrocytic	0.540

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