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STRINGSTRING
COLQ COLQ APP APP CHKB-CPT1B CHKB-CPT1B PHOSPHO1 PHOSPHO1 ACHE ACHE JUN JUN SLC44A1 SLC44A1 CHAT CHAT SLC44A5 SLC44A5 CHKA CHKA SLC44A2 SLC44A2
"ACHE" - acetylcholinesterase in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
ACHEacetylcholinesterase (617 aa)    
Predicted Functional Partners:
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase (455 aa)
        score_image   score_image   0.963
CHAT
choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses (748 aa)
            score_image   0.951
JUN
jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (331 aa)
          score_image score_image   0.933
CHKA
choline kinase alpha; Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline (457 aa)
          score_image score_image   0.931
APP
amyloid beta (A4) precursor protein (770 aa)
        score_image   score_image   0.906
SLC44A1
solute carrier family 44, member 1; Choline transporter. May be involved in membrane synthesis and myelin production (657 aa)
          score_image score_image   0.905
CHKB-CPT1B
CHKB-CPT1B readthrough (non-protein coding) (60 aa)
          score_image     0.900
PHOSPHO1
phosphatase, orphan 1; Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization (292 aa)
          score_image     0.900
SLC44A5
solute carrier family 44, member 5 (719 aa)
          score_image     0.900
SLC44A2
solute carrier family 44, member 2 (706 aa)
          score_image     0.900
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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