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STRINGSTRING
MYC MYC MDM4 MDM4 DHCR24 DHCR24 MDM2 MDM2 UBC UBC MTBP MTBP NEDD8 NEDD8 PSMA3 PSMA3 WDR67 WDR67 ZNF704 ZNF704 SAMD12 SAMD12
"MTBP" - Mdm2, transformed 3T3 cell double minute 2, p53 binding protein in Homo sapiens
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MTBPMdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa; Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation (904 aa)    
Predicted Functional Partners:
MDM2
Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) (497 aa)
        score_image   score_image   0.902
MYC
v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes (454 aa)
            score_image   0.829
PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2 (255 aa)
            score_image   0.560
WDR67
WD repeat domain 67 (1066 aa)
      score_image     score_image   0.543
DHCR24
24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis (516 aa)
            score_image   0.511
UBC
ubiquitin C (685 aa)
        score_image       0.483
ZNF704
zinc finger protein 704 (412 aa)
            score_image   0.475
SAMD12
sterile alpha motif domain containing 12 (201 aa)
            score_image   0.450
MDM4
Mdm4 p53 binding protein homolog (mouse); Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions (490 aa)
        score_image   score_image   0.440
NEDD8
neural precursor cell expressed, developmentally down-regulated 8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (81 aa)
            score_image   0.420
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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