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ADM2 ADM2 POMC POMC VIPR1 VIPR1 GIPR GIPR NPSR1 NPSR1 GLP2R GLP2R GNAS GNAS ADRB2 ADRB2 ADORA2B ADORA2B ADCY3 ADCY3 PTGDR PTGDR
"PTGDR" - prostaglandin D2 receptor in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
PTGDRprostaglandin D2 receptor (DP); Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity) (359 aa)    
Predicted Functional Partners:
GNAS
GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity) (1037 aa)
         score_image score_image score_image   0.965
GLP2R
glucagon-like peptide 2 receptor; This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (553 aa)
           score_image score_image   0.942
NPSR1
neuropeptide S receptor 1 (377 aa)
           score_image score_image   0.936
ADRB2
adrenoceptor beta 2, surface (413 aa)
           score_image score_image   0.928
GIPR
gastric inhibitory polypeptide receptor; This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (466 aa)
           score_image score_image   0.925
ADORA2B
adenosine A2b receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (332 aa)
           score_image score_image   0.919
VIPR1
vasoactive intestinal peptide receptor 1; This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38 (457 aa)
           score_image score_image   0.916
POMC
proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol (267 aa)
           score_image score_image   0.916
ADM2
adrenomedullin 2; IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway (148 aa)
           score_image score_image   0.916
ADCY3
adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration (1144 aa)
           score_image score_image   0.914
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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