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STRINGSTRING
NAPB NAPB VTI1B VTI1B VAMP7 VAMP7 STX10 STX10 VTI1A VTI1A VAMP1 VAMP1 TSNARE1 TSNARE1 YKT6 YKT6 VAMP3 VAMP3 VAMP2 VAMP2 NAPA NAPA
"TSNARE1" - t-SNARE domain containing 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
TSNARE1t-SNARE domain containing 1 (513 aa)    
Predicted Functional Partners:
VAMP7
vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] (260 aa)
      score_image score_image score_image score_image   0.953
VTI1A
vesicle transport through interaction with t-SNAREs homolog 1A (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with [...] (217 aa)
      score_image score_image score_image score_image   0.947
VTI1B
vesicle transport through interaction with t-SNAREs homolog 1B (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence (232 aa)
      score_image score_image score_image score_image   0.932
NAPB
N-ethylmaleimide-sensitive factor attachment protein, beta; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (By similarity) (298 aa)
        score_image score_image score_image   0.914
NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (295 aa)
        score_image score_image score_image   0.914
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2); Involved in the targeting and/or fusion of transport vesicles to their target membrane (116 aa)
        score_image score_image score_image   0.907
YKT6
YKT6 v-SNARE homolog (S. cerevisiae); Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity (198 aa)
      score_image score_image score_image score_image   0.900
VAMP1
vesicle-associated membrane protein 1 (synaptobrevin 1); Involved in the targeting and/or fusion of transport vesicles to their target membrane (118 aa)
        score_image score_image score_image   0.900
VAMP3
vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network (100 aa)
        score_image score_image score_image   0.900
STX10
syntaxin 10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network (249 aa)
        score_image score_image score_image   0.889
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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