node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCK | EDN1 | ENSP00000335657 | ENSP00000368683 | cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | 0.938 |
CCK | GNRH1 | ENSP00000335657 | ENSP00000276414 | cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | 0.925 |
CCK | GRP | ENSP00000335657 | ENSP00000256857 | cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion | gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity) | 0.989 |
CCK | NPS | ENSP00000335657 | ENSP00000381105 | cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | 0.986 |
CCK | NTS | ENSP00000335657 | ENSP00000256010 | cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion | neurotensin; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle | 0.986 |
CCK | OXT | ENSP00000335657 | ENSP00000217386 | cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion | oxytocin/neurophysin I prepropeptide; Neurophysin 1 specifically binds oxytocin | 0.995 |
CCK | TAC1 | ENSP00000335657 | ENSP00000321106 | cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion | tachykinin, precursor 1 | 0.986 |
CCK | TRH | ENSP00000335657 | ENSP00000303452 | cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion | thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes | 0.970 |
CCK | TRHR | ENSP00000335657 | ENSP00000309818 | cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion | thyrotropin-releasing hormone receptor; Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system | 0.933 |
EDN1 | CCK | ENSP00000368683 | ENSP00000335657 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion | 0.938 |
EDN1 | GNRH1 | ENSP00000368683 | ENSP00000276414 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | 0.939 |
EDN1 | GRP | ENSP00000368683 | ENSP00000256857 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity) | 0.951 |
EDN1 | NPS | ENSP00000368683 | ENSP00000381105 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | 0.954 |
EDN1 | NTS | ENSP00000368683 | ENSP00000256010 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | neurotensin; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle | 0.938 |
EDN1 | OXT | ENSP00000368683 | ENSP00000217386 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | oxytocin/neurophysin I prepropeptide; Neurophysin 1 specifically binds oxytocin | 0.961 |
EDN1 | TAC1 | ENSP00000368683 | ENSP00000321106 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | tachykinin, precursor 1 | 0.960 |
EDN1 | TRH | ENSP00000368683 | ENSP00000303452 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes | 0.985 |
EDN1 | TRHR | ENSP00000368683 | ENSP00000309818 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | thyrotropin-releasing hormone receptor; Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system | 0.912 |
GNRH1 | CCK | ENSP00000276414 | ENSP00000335657 | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion | 0.925 |
GNRH1 | EDN1 | ENSP00000276414 | ENSP00000368683 | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | 0.939 |