node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATL1 | REEP4 | ENSP00000351155 | ENSP00000303482 | atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development | receptor accessory protein 4; May enhance the cell surface expression of odorant receptors (By similarity) | 0.478 |
ATL1 | UBC | ENSP00000351155 | ENSP00000344818 | atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development | ubiquitin C | 0.620 |
CDO1 | LPHN1 | ENSP00000250535 | ENSP00000340688 | cysteine dioxygenase, type I; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range | latrophilin 1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis (By similarity) | 0.585 |
CDO1 | LPHN2 | ENSP00000250535 | ENSP00000322270 | cysteine dioxygenase, type I; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range | latrophilin 2 | 0.607 |
CDO1 | LPHN3 | ENSP00000250535 | ENSP00000422533 | cysteine dioxygenase, type I; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range | latrophilin 3 | 0.585 |
CDO1 | REEP4 | ENSP00000250535 | ENSP00000303482 | cysteine dioxygenase, type I; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range | receptor accessory protein 4; May enhance the cell surface expression of odorant receptors (By similarity) | 0.480 |
KDM3B | RAB3GAP1 | ENSP00000326563 | ENSP00000411418 | lysine (K)-specific demethylase 3B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity | RAB3 GTPase activating protein subunit 1 (catalytic); Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters | 0.559 |
KDM3B | RAB3GAP2 | ENSP00000326563 | ENSP00000351832 | lysine (K)-specific demethylase 3B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity | RAB3 GTPase activating protein subunit 2 (non-catalytic); Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters | 0.531 |
KDM3B | REEP4 | ENSP00000326563 | ENSP00000303482 | lysine (K)-specific demethylase 3B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity | receptor accessory protein 4; May enhance the cell surface expression of odorant receptors (By similarity) | 0.598 |
KDM3B | UBC | ENSP00000326563 | ENSP00000344818 | lysine (K)-specific demethylase 3B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity | ubiquitin C | 0.889 |
LPHN1 | CDO1 | ENSP00000340688 | ENSP00000250535 | latrophilin 1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis (By similarity) | cysteine dioxygenase, type I; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range | 0.585 |
LPHN1 | REEP4 | ENSP00000340688 | ENSP00000303482 | latrophilin 1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis (By similarity) | receptor accessory protein 4; May enhance the cell surface expression of odorant receptors (By similarity) | 0.483 |
LPHN2 | CDO1 | ENSP00000322270 | ENSP00000250535 | latrophilin 2 | cysteine dioxygenase, type I; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range | 0.607 |
LPHN2 | REEP4 | ENSP00000322270 | ENSP00000303482 | latrophilin 2 | receptor accessory protein 4; May enhance the cell surface expression of odorant receptors (By similarity) | 0.483 |
LPHN3 | CDO1 | ENSP00000422533 | ENSP00000250535 | latrophilin 3 | cysteine dioxygenase, type I; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range | 0.585 |
LPHN3 | REEP4 | ENSP00000422533 | ENSP00000303482 | latrophilin 3 | receptor accessory protein 4; May enhance the cell surface expression of odorant receptors (By similarity) | 0.483 |
LRRK2 | REEP4 | ENSP00000298910 | ENSP00000303482 | leucine-rich repeat kinase 2; May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes | receptor accessory protein 4; May enhance the cell surface expression of odorant receptors (By similarity) | 0.467 |
LRRK2 | UBC | ENSP00000298910 | ENSP00000344818 | leucine-rich repeat kinase 2; May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes | ubiquitin C | 0.873 |
RAB3GAP1 | KDM3B | ENSP00000411418 | ENSP00000326563 | RAB3 GTPase activating protein subunit 1 (catalytic); Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters | lysine (K)-specific demethylase 3B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity | 0.559 |
RAB3GAP1 | RAB3GAP2 | ENSP00000411418 | ENSP00000351832 | RAB3 GTPase activating protein subunit 1 (catalytic); Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters | RAB3 GTPase activating protein subunit 2 (non-catalytic); Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters | 0.996 |