BAHCC1 protein (Homo sapiens) - STRING network view

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BAHCC1

BAH domain and coiled-coil containing 1 (2608 aa)

Predicted Functional Partners:

EYA4

0.704

EYA1

0.704

EYA2

0.704

FAM184B

0.597

TTLL10

0.532

UNC79

0.509

TBC1D22A

0.508

TTLL5

0.472

KIAA1324

0.457

WDR61

0.457

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAHCC1	EYA1	ENSP00000303486	ENSP00000342626	BAH domain and coiled-coil containing 1	eyes absent homolog 1 (Drosophila); Tyrosine phosphatase that specifically dephosphorylates ’Tyr-142’ of histone H2AX (H2AXY142ph). ’Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Seems to coactivate SIX2, SIX4 and SIX5. May be [...]	0.704
BAHCC1	EYA2	ENSP00000303486	ENSP00000333640	BAH domain and coiled-coil containing 1	eyes absent homolog 2 (Drosophila)	0.704
BAHCC1	EYA4	ENSP00000303486	ENSP00000347294	BAH domain and coiled-coil containing 1	eyes absent homolog 4 (Drosophila); Tyrosine phosphatase that specifically dephosphorylates ’Tyr-142’ of histone H2AX (H2AXY142ph). ’Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By si [...]	0.704
BAHCC1	FAM184B	ENSP00000303486	ENSP00000265018	BAH domain and coiled-coil containing 1	family with sequence similarity 184, member B	0.597
BAHCC1	KIAA1324	ENSP00000303486	ENSP00000358955	BAH domain and coiled-coil containing 1	KIAA1324; May play a role as a marker of hyperestrogenic state and estrogen-related type I endometrial carcinoma	0.457
BAHCC1	TBC1D22A	ENSP00000303486	ENSP00000336724	BAH domain and coiled-coil containing 1	TBC1 domain family, member 22A	0.508
BAHCC1	TTLL10	ENSP00000303486	ENSP00000368591	BAH domain and coiled-coil containing 1	tubulin tyrosine ligase-like family, member 10; Inactive polyglycylase	0.532
BAHCC1	TTLL5	ENSP00000303486	ENSP00000298832	BAH domain and coiled-coil containing 1	tubulin tyrosine ligase-like family, member 5; Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction	0.472
BAHCC1	UNC79	ENSP00000303486	ENSP00000256339	BAH domain and coiled-coil containing 1	unc-79 homolog (C. elegans); Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability (By similarity)	0.509
BAHCC1	WDR61	ENSP00000303486	ENSP00000267973	BAH domain and coiled-coil containing 1	WD repeat domain 61; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and ’Ser-2’- and ’Ser-5’-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target gene [...]	0.457
EYA1	BAHCC1	ENSP00000342626	ENSP00000303486	eyes absent homolog 1 (Drosophila); Tyrosine phosphatase that specifically dephosphorylates ’Tyr-142’ of histone H2AX (H2AXY142ph). ’Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Seems to coactivate SIX2, SIX4 and SIX5. May be [...]	BAH domain and coiled-coil containing 1	0.704
EYA2	BAHCC1	ENSP00000333640	ENSP00000303486	eyes absent homolog 2 (Drosophila)	BAH domain and coiled-coil containing 1	0.704
EYA4	BAHCC1	ENSP00000347294	ENSP00000303486	eyes absent homolog 4 (Drosophila); Tyrosine phosphatase that specifically dephosphorylates ’Tyr-142’ of histone H2AX (H2AXY142ph). ’Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By si [...]	BAH domain and coiled-coil containing 1	0.704
FAM184B	BAHCC1	ENSP00000265018	ENSP00000303486	family with sequence similarity 184, member B	BAH domain and coiled-coil containing 1	0.597
FAM184B	UNC79	ENSP00000265018	ENSP00000256339	family with sequence similarity 184, member B	unc-79 homolog (C. elegans); Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability (By similarity)	0.601
KIAA1324	BAHCC1	ENSP00000358955	ENSP00000303486	KIAA1324; May play a role as a marker of hyperestrogenic state and estrogen-related type I endometrial carcinoma	BAH domain and coiled-coil containing 1	0.457
TBC1D22A	BAHCC1	ENSP00000336724	ENSP00000303486	TBC1 domain family, member 22A	BAH domain and coiled-coil containing 1	0.508
TTLL10	BAHCC1	ENSP00000368591	ENSP00000303486	tubulin tyrosine ligase-like family, member 10; Inactive polyglycylase	BAH domain and coiled-coil containing 1	0.532
TTLL5	BAHCC1	ENSP00000298832	ENSP00000303486	tubulin tyrosine ligase-like family, member 5; Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction	BAH domain and coiled-coil containing 1	0.472
UNC79	BAHCC1	ENSP00000256339	ENSP00000303486	unc-79 homolog (C. elegans); Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability (By similarity)	BAH domain and coiled-coil containing 1	0.509

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