DEFB4A protein (Homo sapiens) - STRING network view

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Score

DEFB4A

defensin, beta 4A; Has antibacterial activity (Potential) (64 aa)

Predicted Functional Partners:

TLR4

0.916

DEFB1

0.808

DEFB103B

0.720

DEFB104A

0.658

DEFB103A

0.634

DEFB4B

0.576

CCR6

0.576

DEFB105A

0.506

DEFB107A

0.472

C14orf80

0.418

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C14orf80	DEFB104A	ENSP00000376307	ENSP00000320813	chromosome 14 open reading frame 80	defensin, beta 104A; Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103	0.583
C14orf80	DEFB107A	ENSP00000376307	ENSP00000334681	chromosome 14 open reading frame 80	defensin, beta 107A; Has antibacterial activity (Potential)	0.700
C14orf80	DEFB4A	ENSP00000376307	ENSP00000303532	chromosome 14 open reading frame 80	defensin, beta 4A; Has antibacterial activity (Potential)	0.418
CCR6	DEFB1	ENSP00000339393	ENSP00000297439	chemokine (C-C motif) receptor 6; Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level	defensin, beta 1; Has bactericidal activity (By similarity)	0.965
CCR6	DEFB103B	ENSP00000339393	ENSP00000324633	chemokine (C-C motif) receptor 6; Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level	defensin, beta 103B; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed	0.683
CCR6	DEFB4A	ENSP00000339393	ENSP00000303532	chemokine (C-C motif) receptor 6; Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level	defensin, beta 4A; Has antibacterial activity (Potential)	0.576
DEFB1	CCR6	ENSP00000297439	ENSP00000339393	defensin, beta 1; Has bactericidal activity (By similarity)	chemokine (C-C motif) receptor 6; Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level	0.965
DEFB1	DEFB103A	ENSP00000297439	ENSP00000320951	defensin, beta 1; Has bactericidal activity (By similarity)	defensin, beta 103A; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed	0.788
DEFB1	DEFB103B	ENSP00000297439	ENSP00000324633	defensin, beta 1; Has bactericidal activity (By similarity)	defensin, beta 103B; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed	0.783
DEFB1	DEFB104A	ENSP00000297439	ENSP00000320813	defensin, beta 1; Has bactericidal activity (By similarity)	defensin, beta 104A; Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103	0.414
DEFB1	DEFB4A	ENSP00000297439	ENSP00000303532	defensin, beta 1; Has bactericidal activity (By similarity)	defensin, beta 4A; Has antibacterial activity (Potential)	0.808
DEFB1	DEFB4B	ENSP00000297439	ENSP00000424598	defensin, beta 1; Has bactericidal activity (By similarity)	defensin, beta 4B; Has antibacterial activity (Potential)	0.580
DEFB1	TLR4	ENSP00000297439	ENSP00000363089	defensin, beta 1; Has bactericidal activity (By similarity)	toll-like receptor 4	0.502
DEFB103A	DEFB1	ENSP00000320951	ENSP00000297439	defensin, beta 103A; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed	defensin, beta 1; Has bactericidal activity (By similarity)	0.788
DEFB103A	DEFB103B	ENSP00000320951	ENSP00000324633	defensin, beta 103A; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed	defensin, beta 103B; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed	0.576
DEFB103A	DEFB104A	ENSP00000320951	ENSP00000320813	defensin, beta 103A; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed	defensin, beta 104A; Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103	0.473
DEFB103A	DEFB105A	ENSP00000320951	ENSP00000334330	defensin, beta 103A; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed	defensin, beta 105A; Has antibacterial activity (Potential)	0.473
DEFB103A	DEFB107A	ENSP00000320951	ENSP00000334681	defensin, beta 103A; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed	defensin, beta 107A; Has antibacterial activity (Potential)	0.473
DEFB103A	DEFB4A	ENSP00000320951	ENSP00000303532	defensin, beta 103A; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed	defensin, beta 4A; Has antibacterial activity (Potential)	0.634
DEFB103B	CCR6	ENSP00000324633	ENSP00000339393	defensin, beta 103B; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed	chemokine (C-C motif) receptor 6; Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level	0.683

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