node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKMY2 | COG5 | ENSP00000303570 | ENSP00000297135 | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | component of oligomeric golgi complex 5; Required for normal Golgi function (By similarity) | 0.582 |
ANKMY2 | IFRD1 | ENSP00000303570 | ENSP00000005558 | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity) | 0.610 |
ANKMY2 | IFRD2 | ENSP00000303570 | ENSP00000398971 | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | interferon-related developmental regulator 2 | 0.585 |
ANKMY2 | IFT122 | ENSP00000303570 | ENSP00000296266 | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | 0.585 |
ANKMY2 | IFT140 | ENSP00000303570 | ENSP00000406012 | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance | 0.526 |
ANKMY2 | PIK3CG | ENSP00000303570 | ENSP00000352121 | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukoc [...] | 0.606 |
ANKMY2 | PTCHD3 | ENSP00000303570 | ENSP00000417658 | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | patched domain containing 3; May play a role in sperm development or sperm function | 0.711 |
ANKMY2 | RPRD1A | ENSP00000303570 | ENSP00000349955 | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | regulation of nuclear pre-mRNA domain containing 1A; Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle | 0.538 |
ANKMY2 | SOSTDC1 | ENSP00000303570 | ENSP00000304930 | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | sclerostin domain containing 1; May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner | 0.530 |
ANKMY2 | STAT5B | ENSP00000303570 | ENSP00000293328 | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | signal transducer and activator of transcription 5B; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription | 0.538 |
COG5 | ANKMY2 | ENSP00000297135 | ENSP00000303570 | component of oligomeric golgi complex 5; Required for normal Golgi function (By similarity) | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | 0.582 |
COG5 | PIK3CG | ENSP00000297135 | ENSP00000352121 | component of oligomeric golgi complex 5; Required for normal Golgi function (By similarity) | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukoc [...] | 0.549 |
IFRD1 | ANKMY2 | ENSP00000005558 | ENSP00000303570 | interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity) | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | 0.610 |
IFRD1 | PIK3CG | ENSP00000005558 | ENSP00000352121 | interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity) | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukoc [...] | 0.445 |
IFRD2 | ANKMY2 | ENSP00000398971 | ENSP00000303570 | interferon-related developmental regulator 2 | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | 0.585 |
IFT122 | ANKMY2 | ENSP00000296266 | ENSP00000303570 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | 0.585 |
IFT122 | IFT140 | ENSP00000296266 | ENSP00000406012 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance | 0.975 |
IFT122 | PTCHD3 | ENSP00000296266 | ENSP00000417658 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | patched domain containing 3; May play a role in sperm development or sperm function | 0.664 |
IFT140 | ANKMY2 | ENSP00000406012 | ENSP00000303570 | intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | 0.526 |
IFT140 | IFT122 | ENSP00000406012 | ENSP00000296266 | intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | 0.975 |