node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABR | ARHGAP20 | ENSP00000303909 | ENSP00000260283 | active BCR-related | Rho GTPase activating protein 20 | 0.920 |
ABR | ARHGDIA | ENSP00000303909 | ENSP00000269321 | active BCR-related | Rho GDP dissociation inhibitor (GDI) alpha; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity) | 0.983 |
ABR | CDC42 | ENSP00000303909 | ENSP00000314458 | active BCR-related | cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration | 0.929 |
ABR | MCF2 | ENSP00000303909 | ENSP00000430276 | active BCR-related | MCF.2 cell line derived transforming sequence | 0.940 |
ABR | RAC1 | ENSP00000303909 | ENSP00000348461 | active BCR-related | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] | 0.928 |
ABR | RAC2 | ENSP00000303909 | ENSP00000249071 | active BCR-related | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase | 0.933 |
ABR | RAC3 | ENSP00000303909 | ENSP00000304283 | active BCR-related | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles | 0.927 |
ABR | TIAM1 | ENSP00000303909 | ENSP00000286827 | active BCR-related | T-cell lymphoma invasion and metastasis 1; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA | 0.922 |
ABR | VAV1 | ENSP00000303909 | ENSP00000472929 | active BCR-related | vav 1 guanine nucleotide exchange factor; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation | 0.935 |
ABR | VAV2 | ENSP00000303909 | ENSP00000360916 | active BCR-related | vav 2 guanine nucleotide exchange factor | 0.925 |
ARHGAP20 | ABR | ENSP00000260283 | ENSP00000303909 | Rho GTPase activating protein 20 | active BCR-related | 0.920 |
ARHGAP20 | ARHGDIA | ENSP00000260283 | ENSP00000269321 | Rho GTPase activating protein 20 | Rho GDP dissociation inhibitor (GDI) alpha; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity) | 0.906 |
ARHGAP20 | CDC42 | ENSP00000260283 | ENSP00000314458 | Rho GTPase activating protein 20 | cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration | 0.920 |
ARHGAP20 | MCF2 | ENSP00000260283 | ENSP00000430276 | Rho GTPase activating protein 20 | MCF.2 cell line derived transforming sequence | 0.901 |
ARHGAP20 | RAC2 | ENSP00000260283 | ENSP00000249071 | Rho GTPase activating protein 20 | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase | 0.900 |
ARHGAP20 | RAC3 | ENSP00000260283 | ENSP00000304283 | Rho GTPase activating protein 20 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles | 0.913 |
ARHGAP20 | TIAM1 | ENSP00000260283 | ENSP00000286827 | Rho GTPase activating protein 20 | T-cell lymphoma invasion and metastasis 1; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA | 0.915 |
ARHGAP20 | VAV1 | ENSP00000260283 | ENSP00000472929 | Rho GTPase activating protein 20 | vav 1 guanine nucleotide exchange factor; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation | 0.906 |
ARHGAP20 | VAV2 | ENSP00000260283 | ENSP00000360916 | Rho GTPase activating protein 20 | vav 2 guanine nucleotide exchange factor | 0.910 |
ARHGDIA | ABR | ENSP00000269321 | ENSP00000303909 | Rho GDP dissociation inhibitor (GDI) alpha; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity) | active BCR-related | 0.983 |