node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGAP5 | BABAM1 | ENSP00000363207 | ENSP00000352408 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 5; Putative GTPase-activating protein (Potential) | BRISC and BRCA1 A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes ’Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ’Lys-63’-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprote [...] | 0.412 |
AGAP5 | SLX1A | ENSP00000363207 | ENSP00000251303 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 5; Putative GTPase-activating protein (Potential) | SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae); Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5’-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products | 0.475 |
AGAP5 | TMEM223 | ENSP00000363207 | ENSP00000303987 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 5; Putative GTPase-activating protein (Potential) | transmembrane protein 223 | 0.756 |
AGAP5 | UBE2NL | ENSP00000363207 | ENSP00000359525 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 5; Putative GTPase-activating protein (Potential) | ubiquitin-conjugating enzyme E2N-like | 0.564 |
BABAM1 | AGAP5 | ENSP00000352408 | ENSP00000363207 | BRISC and BRCA1 A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes ’Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ’Lys-63’-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprote [...] | ArfGAP with GTPase domain, ankyrin repeat and PH domain 5; Putative GTPase-activating protein (Potential) | 0.412 |
BABAM1 | TMEM223 | ENSP00000352408 | ENSP00000303987 | BRISC and BRCA1 A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes ’Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ’Lys-63’-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprote [...] | transmembrane protein 223 | 0.505 |
BABAM1 | UBC | ENSP00000352408 | ENSP00000344818 | BRISC and BRCA1 A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes ’Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ’Lys-63’-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprote [...] | ubiquitin C | 0.948 |
BIN3 | TMEM223 | ENSP00000276416 | ENSP00000303987 | bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin | transmembrane protein 223 | 0.450 |
SLX1A | AGAP5 | ENSP00000251303 | ENSP00000363207 | SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae); Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5’-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products | ArfGAP with GTPase domain, ankyrin repeat and PH domain 5; Putative GTPase-activating protein (Potential) | 0.475 |
SLX1A | TMEM223 | ENSP00000251303 | ENSP00000303987 | SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae); Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5’-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products | transmembrane protein 223 | 0.563 |
TMEM223 | AGAP5 | ENSP00000303987 | ENSP00000363207 | transmembrane protein 223 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 5; Putative GTPase-activating protein (Potential) | 0.756 |
TMEM223 | BABAM1 | ENSP00000303987 | ENSP00000352408 | transmembrane protein 223 | BRISC and BRCA1 A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes ’Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ’Lys-63’-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprote [...] | 0.505 |
TMEM223 | BIN3 | ENSP00000303987 | ENSP00000276416 | transmembrane protein 223 | bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin | 0.450 |
TMEM223 | SLX1A | ENSP00000303987 | ENSP00000251303 | transmembrane protein 223 | SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae); Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5’-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products | 0.563 |
TMEM223 | UBC | ENSP00000303987 | ENSP00000344818 | transmembrane protein 223 | ubiquitin C | 0.483 |
TMEM223 | UBE2NL | ENSP00000303987 | ENSP00000359525 | transmembrane protein 223 | ubiquitin-conjugating enzyme E2N-like | 0.643 |
UBC | BABAM1 | ENSP00000344818 | ENSP00000352408 | ubiquitin C | BRISC and BRCA1 A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes ’Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ’Lys-63’-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprote [...] | 0.948 |
UBC | TMEM223 | ENSP00000344818 | ENSP00000303987 | ubiquitin C | transmembrane protein 223 | 0.483 |
UBC | UBE2NL | ENSP00000344818 | ENSP00000359525 | ubiquitin C | ubiquitin-conjugating enzyme E2N-like | 0.956 |
UBE2NL | AGAP5 | ENSP00000359525 | ENSP00000363207 | ubiquitin-conjugating enzyme E2N-like | ArfGAP with GTPase domain, ankyrin repeat and PH domain 5; Putative GTPase-activating protein (Potential) | 0.564 |