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STRINGSTRING
BIN3 BIN3 SLX1A SLX1A AGAP5 AGAP5 TMEM223 TMEM223 UBE2NL UBE2NL BABAM1 BABAM1 UBC UBC
"TMEM223" - transmembrane protein 223 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Experiments
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[Homology]
Score
TMEM223transmembrane protein 223 (202 aa)    
Predicted Functional Partners:
AGAP5
ArfGAP with GTPase domain, ankyrin repeat and PH domain 5; Putative GTPase-activating protein (Potential) (686 aa)
            score_image   0.756
UBE2NL
ubiquitin-conjugating enzyme E2N-like (153 aa)
            score_image   0.643
SLX1A
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae); Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5’-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products (275 aa)
            score_image   0.563
BABAM1
BRISC and BRCA1 A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes ’Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ’Lys-63’-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprote [...] (329 aa)
            score_image   0.505
UBC
ubiquitin C (685 aa)
        score_image       0.483
BIN3
bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin (253 aa)
            score_image   0.450
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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