ANKRD27 protein (Homo sapiens) - STRING network view

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ANKRD27

ankyrin repeat domain 27 (VPS9 domain); May be a Rab21 guanine exchange factor and regulate endosome dynamics (By similarity) (1050 aa)

Predicted Functional Partners:

RAB32

0.987

RAB21

0.924

RAB38

0.919

VAMP7

0.770

SELV

0.723

STYK1

0.662

KIF5A

0.660

UBC

0.645

HELT

0.645

GPR83

0.645

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD27	GPR83	ENSP00000304292	ENSP00000243673	ankyrin repeat domain 27 (VPS9 domain); May be a Rab21 guanine exchange factor and regulate endosome dynamics (By similarity)	G protein-coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor	0.645
ANKRD27	HELT	ENSP00000304292	ENSP00000343464	ankyrin repeat domain 27 (VPS9 domain); May be a Rab21 guanine exchange factor and regulate endosome dynamics (By similarity)	helt bHLH transcription factor; Transcriptional repressor which binds preferentially to the canonical E box sequence 5’-CACGCG-3’ (By similarity)	0.645
ANKRD27	KIF5A	ENSP00000304292	ENSP00000408979	ankyrin repeat domain 27 (VPS9 domain); May be a Rab21 guanine exchange factor and regulate endosome dynamics (By similarity)	kinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity)	0.660
ANKRD27	RAB21	ENSP00000304292	ENSP00000261263	ankyrin repeat domain 27 (VPS9 domain); May be a Rab21 guanine exchange factor and regulate endosome dynamics (By similarity)	RAB21, member RAS oncogene family; Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis	0.924
ANKRD27	RAB32	ENSP00000304292	ENSP00000356465	ankyrin repeat domain 27 (VPS9 domain); May be a Rab21 guanine exchange factor and regulate endosome dynamics (By similarity)	RAB32, member RAS oncogene family; Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis	0.987
ANKRD27	RAB38	ENSP00000304292	ENSP00000243662	ankyrin repeat domain 27 (VPS9 domain); May be a Rab21 guanine exchange factor and regulate endosome dynamics (By similarity)	RAB38, member RAS oncogene family; May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis	0.919
ANKRD27	SELV	ENSP00000304292	ENSP00000333956	ankyrin repeat domain 27 (VPS9 domain); May be a Rab21 guanine exchange factor and regulate endosome dynamics (By similarity)	selenoprotein V ; May be involved in a redox-related process (Potential)	0.723
ANKRD27	STYK1	ENSP00000304292	ENSP00000075503	ankyrin repeat domain 27 (VPS9 domain); May be a Rab21 guanine exchange factor and regulate endosome dynamics (By similarity)	serine/threonine/tyrosine kinase 1; Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3’-kinases (PI3K) pathways (By similarity)	0.662
ANKRD27	UBC	ENSP00000304292	ENSP00000344818	ankyrin repeat domain 27 (VPS9 domain); May be a Rab21 guanine exchange factor and regulate endosome dynamics (By similarity)	ubiquitin C	0.645
ANKRD27	VAMP7	ENSP00000304292	ENSP00000262640	ankyrin repeat domain 27 (VPS9 domain); May be a Rab21 guanine exchange factor and regulate endosome dynamics (By similarity)	vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...]	0.770
GPR83	ANKRD27	ENSP00000243673	ENSP00000304292	G protein-coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor	ankyrin repeat domain 27 (VPS9 domain); May be a Rab21 guanine exchange factor and regulate endosome dynamics (By similarity)	0.645
GPR83	HELT	ENSP00000243673	ENSP00000343464	G protein-coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor	helt bHLH transcription factor; Transcriptional repressor which binds preferentially to the canonical E box sequence 5’-CACGCG-3’ (By similarity)	0.874
GPR83	SELV	ENSP00000243673	ENSP00000333956	G protein-coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor	selenoprotein V ; May be involved in a redox-related process (Potential)	0.909
GPR83	STYK1	ENSP00000243673	ENSP00000075503	G protein-coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor	serine/threonine/tyrosine kinase 1; Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3’-kinases (PI3K) pathways (By similarity)	0.871
HELT	ANKRD27	ENSP00000343464	ENSP00000304292	helt bHLH transcription factor; Transcriptional repressor which binds preferentially to the canonical E box sequence 5’-CACGCG-3’ (By similarity)	ankyrin repeat domain 27 (VPS9 domain); May be a Rab21 guanine exchange factor and regulate endosome dynamics (By similarity)	0.645
HELT	GPR83	ENSP00000343464	ENSP00000243673	helt bHLH transcription factor; Transcriptional repressor which binds preferentially to the canonical E box sequence 5’-CACGCG-3’ (By similarity)	G protein-coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor	0.874
HELT	SELV	ENSP00000343464	ENSP00000333956	helt bHLH transcription factor; Transcriptional repressor which binds preferentially to the canonical E box sequence 5’-CACGCG-3’ (By similarity)	selenoprotein V ; May be involved in a redox-related process (Potential)	0.907
HELT	STYK1	ENSP00000343464	ENSP00000075503	helt bHLH transcription factor; Transcriptional repressor which binds preferentially to the canonical E box sequence 5’-CACGCG-3’ (By similarity)	serine/threonine/tyrosine kinase 1; Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3’-kinases (PI3K) pathways (By similarity)	0.870
KIF5A	ANKRD27	ENSP00000408979	ENSP00000304292	kinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity)	ankyrin repeat domain 27 (VPS9 domain); May be a Rab21 guanine exchange factor and regulate endosome dynamics (By similarity)	0.660
KIF5A	UBC	ENSP00000408979	ENSP00000344818	kinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity)	ubiquitin C	0.663

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