node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SNX32 | SNX4 | ENSP00000310620 | ENSP00000251775 | sorting nexin 32; May be involved in several stages of intracellular trafficking (By similarity) | sorting nexin 4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation | 0.816 |
SNX32 | SNX7 | ENSP00000310620 | ENSP00000304429 | sorting nexin 32; May be involved in several stages of intracellular trafficking (By similarity) | sorting nexin 7 | 0.847 |
SNX32 | VPS29 | ENSP00000310620 | ENSP00000380795 | sorting nexin 32; May be involved in several stages of intracellular trafficking (By similarity) | vacuolar protein sorting 29 homolog (S. cerevisiae); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) | 0.656 |
SNX32 | VPS35 | ENSP00000310620 | ENSP00000299138 | sorting nexin 32; May be involved in several stages of intracellular trafficking (By similarity) | vacuolar protein sorting 35 homolog (S. cerevisiae) | 0.572 |
SNX4 | SNX32 | ENSP00000251775 | ENSP00000310620 | sorting nexin 4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation | sorting nexin 32; May be involved in several stages of intracellular trafficking (By similarity) | 0.816 |
SNX4 | SNX5 | ENSP00000251775 | ENSP00000366988 | sorting nexin 4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation | sorting nexin 5; May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation | 0.865 |
SNX4 | SNX6 | ENSP00000251775 | ENSP00000355217 | sorting nexin 4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation | sorting nexin 6; May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B (By similarity). Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. May contribute to transcription regulation | 0.966 |
SNX4 | SNX7 | ENSP00000251775 | ENSP00000304429 | sorting nexin 4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation | sorting nexin 7 | 0.624 |
SNX4 | VPS26A | ENSP00000251775 | ENSP00000263559 | sorting nexin 4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation | vacuolar protein sorting 26 homolog A (S. pombe); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) | 0.813 |
SNX4 | VPS26B | ENSP00000251775 | ENSP00000281187 | sorting nexin 4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation | vacuolar protein sorting 26 homolog B (S. pombe); Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network (By similarity) | 0.731 |
SNX4 | VPS29 | ENSP00000251775 | ENSP00000380795 | sorting nexin 4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation | vacuolar protein sorting 29 homolog (S. cerevisiae); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) | 0.869 |
SNX4 | VPS35 | ENSP00000251775 | ENSP00000299138 | sorting nexin 4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation | vacuolar protein sorting 35 homolog (S. cerevisiae) | 0.828 |
SNX5 | SNX4 | ENSP00000366988 | ENSP00000251775 | sorting nexin 5; May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation | sorting nexin 4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation | 0.865 |
SNX5 | SNX7 | ENSP00000366988 | ENSP00000304429 | sorting nexin 5; May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation | sorting nexin 7 | 0.608 |
SNX5 | VPS26A | ENSP00000366988 | ENSP00000263559 | sorting nexin 5; May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation | vacuolar protein sorting 26 homolog A (S. pombe); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) | 0.722 |
SNX5 | VPS26B | ENSP00000366988 | ENSP00000281187 | sorting nexin 5; May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation | vacuolar protein sorting 26 homolog B (S. pombe); Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network (By similarity) | 0.644 |
SNX5 | VPS29 | ENSP00000366988 | ENSP00000380795 | sorting nexin 5; May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation | vacuolar protein sorting 29 homolog (S. cerevisiae); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) | 0.767 |
SNX5 | VPS35 | ENSP00000366988 | ENSP00000299138 | sorting nexin 5; May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation | vacuolar protein sorting 35 homolog (S. cerevisiae) | 0.762 |
SNX6 | SNX4 | ENSP00000355217 | ENSP00000251775 | sorting nexin 6; May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B (By similarity). Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. May contribute to transcription regulation | sorting nexin 4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation | 0.966 |
SNX6 | SNX7 | ENSP00000355217 | ENSP00000304429 | sorting nexin 6; May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B (By similarity). Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. May contribute to transcription regulation | sorting nexin 7 | 0.895 |