node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCC5 | HAS3 | ENSP00000333926 | ENSP00000304440 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | 0.907 |
CD44 | HAS3 | ENSP00000398632 | ENSP00000304440 | CD44 molecule (Indian blood group) | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | 0.717 |
CD44 | HMMR | ENSP00000398632 | ENSP00000377492 | CD44 molecule (Indian blood group) | hyaluronan-mediated motility receptor (RHAMM); Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity | 0.982 |
CD44 | HYAL2 | ENSP00000398632 | ENSP00000350387 | CD44 molecule (Indian blood group) | hyaluronoglucosaminidase 2; Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R | 0.878 |
CIRH1A | HAS3 | ENSP00000327179 | ENSP00000304440 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | 0.863 |
CIRH1A | SNTB2 | ENSP00000327179 | ENSP00000338191 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2); Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN | 0.759 |
FCHO1 | HAS3 | ENSP00000252771 | ENSP00000304440 | FCH domain only 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | 0.741 |
FCHO2 | HAS3 | ENSP00000393776 | ENSP00000304440 | FCH domain only 2; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocyto [...] | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | 0.741 |
GAS7 | HAS3 | ENSP00000407552 | ENSP00000304440 | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | 0.749 |
HAS3 | ABCC5 | ENSP00000304440 | ENSP00000333926 | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 0.907 |
HAS3 | CD44 | ENSP00000304440 | ENSP00000398632 | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | CD44 molecule (Indian blood group) | 0.717 |
HAS3 | CIRH1A | ENSP00000304440 | ENSP00000327179 | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | 0.863 |
HAS3 | FCHO1 | ENSP00000304440 | ENSP00000252771 | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | FCH domain only 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors | 0.741 |
HAS3 | FCHO2 | ENSP00000304440 | ENSP00000393776 | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | FCH domain only 2; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocyto [...] | 0.741 |
HAS3 | GAS7 | ENSP00000304440 | ENSP00000407552 | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | 0.749 |
HAS3 | HMMR | ENSP00000304440 | ENSP00000377492 | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | hyaluronan-mediated motility receptor (RHAMM); Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity | 0.724 |
HAS3 | HYAL2 | ENSP00000304440 | ENSP00000350387 | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | hyaluronoglucosaminidase 2; Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R | 0.846 |
HAS3 | JAK2 | ENSP00000304440 | ENSP00000371067 | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | Janus kinase 2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylate [...] | 0.808 |
HAS3 | SNTB2 | ENSP00000304440 | ENSP00000338191 | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2); Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN | 0.757 |
HMMR | CD44 | ENSP00000377492 | ENSP00000398632 | hyaluronan-mediated motility receptor (RHAMM); Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity | CD44 molecule (Indian blood group) | 0.982 |