node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTR6 | CFDP1 | ENSP00000188312 | ENSP00000283882 | ARP6 actin-related protein 6 homolog (yeast) | craniofacial development protein 1; May play a role during embryogenesis (By similarity) | 0.890 |
ACTR6 | EP400 | ENSP00000188312 | ENSP00000374212 | ARP6 actin-related protein 6 homolog (yeast) | E1A binding protein p400; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the associ [...] | 0.878 |
ACTR6 | H2AFV | ENSP00000188312 | ENSP00000308405 | ARP6 actin-related protein 6 homolog (yeast) | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | 0.852 |
ACTR6 | H2AFZ | ENSP00000188312 | ENSP00000296417 | ARP6 actin-related protein 6 homolog (yeast) | H2A histone family, member Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | 0.937 |
ACTR6 | MRGBP | ENSP00000188312 | ENSP00000359518 | ARP6 actin-related protein 6 homolog (yeast) | MRG/MORF4L binding protein; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] | 0.427 |
ACTR6 | RUVBL1 | ENSP00000188312 | ENSP00000318297 | ARP6 actin-related protein 6 homolog (yeast) | RuvB-like 1 (E. coli); May be able to bind plasminogen at cell surface and enhance plasminogen activation | 0.933 |
ACTR6 | RUVBL2 | ENSP00000188312 | ENSP00000473172 | ARP6 actin-related protein 6 homolog (yeast) | RuvB-like 2 (E. coli); Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5’ to 3’) activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity | 0.922 |
ACTR6 | SRCAP | ENSP00000188312 | ENSP00000262518 | ARP6 actin-related protein 6 homolog (yeast) | Snf2-related CREBBP activator protein; Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription | 0.876 |
ACTR6 | VPS72 | ENSP00000188312 | ENSP00000357887 | ARP6 actin-related protein 6 homolog (yeast) | vacuolar protein sorting 72 homolog (S. cerevisiae); Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and remodeling | 0.981 |
ACTR6 | ZNHIT1 | ENSP00000188312 | ENSP00000304593 | ARP6 actin-related protein 6 homolog (yeast) | zinc finger, HIT-type containing 1; Seems to play a role in p53-mediated apoptosis induction | 0.988 |
CFDP1 | ACTR6 | ENSP00000283882 | ENSP00000188312 | craniofacial development protein 1; May play a role during embryogenesis (By similarity) | ARP6 actin-related protein 6 homolog (yeast) | 0.890 |
CFDP1 | EP400 | ENSP00000283882 | ENSP00000374212 | craniofacial development protein 1; May play a role during embryogenesis (By similarity) | E1A binding protein p400; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the associ [...] | 0.644 |
CFDP1 | H2AFV | ENSP00000283882 | ENSP00000308405 | craniofacial development protein 1; May play a role during embryogenesis (By similarity) | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | 0.891 |
CFDP1 | H2AFZ | ENSP00000283882 | ENSP00000296417 | craniofacial development protein 1; May play a role during embryogenesis (By similarity) | H2A histone family, member Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | 0.908 |
CFDP1 | MRGBP | ENSP00000283882 | ENSP00000359518 | craniofacial development protein 1; May play a role during embryogenesis (By similarity) | MRG/MORF4L binding protein; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] | 0.646 |
CFDP1 | RUVBL1 | ENSP00000283882 | ENSP00000318297 | craniofacial development protein 1; May play a role during embryogenesis (By similarity) | RuvB-like 1 (E. coli); May be able to bind plasminogen at cell surface and enhance plasminogen activation | 0.955 |
CFDP1 | RUVBL2 | ENSP00000283882 | ENSP00000473172 | craniofacial development protein 1; May play a role during embryogenesis (By similarity) | RuvB-like 2 (E. coli); Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5’ to 3’) activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity | 0.927 |
CFDP1 | SRCAP | ENSP00000283882 | ENSP00000262518 | craniofacial development protein 1; May play a role during embryogenesis (By similarity) | Snf2-related CREBBP activator protein; Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription | 0.997 |
CFDP1 | VPS72 | ENSP00000283882 | ENSP00000357887 | craniofacial development protein 1; May play a role during embryogenesis (By similarity) | vacuolar protein sorting 72 homolog (S. cerevisiae); Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and remodeling | 0.978 |
CFDP1 | ZNHIT1 | ENSP00000283882 | ENSP00000304593 | craniofacial development protein 1; May play a role during embryogenesis (By similarity) | zinc finger, HIT-type containing 1; Seems to play a role in p53-mediated apoptosis induction | 0.917 |