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VCP VCP SPATA5 SPATA5 UBE2G2 UBE2G2 MARCH8 MARCH8 MARCH6 MARCH6 MARCH11 MARCH11 MARCH3 MARCH3 RNFT1 RNFT1 MARCH10 MARCH10 ATAD2B ATAD2B SPATA5L1 SPATA5L1
"RNFT1" - ring finger protein, transmembrane 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
RNFT1ring finger protein, transmembrane 1 (435 aa)    
Predicted Functional Partners:
VCP
valosin containing protein; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the e [...] (806 aa)
        score_image   score_image   0.753
SPATA5L1
spermatogenesis associated 5-like 1 (753 aa)
        score_image   score_image   0.753
SPATA5
spermatogenesis associated 5; May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By similarity) (893 aa)
        score_image   score_image   0.753
ATAD2B
ATPase family, AAA domain containing 2B (1458 aa)
        score_image   score_image   0.753
UBE2G2
ubiquitin-conjugating enzyme E2G 2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Involved in endoplasmic reticulum- associated degradation (ERAD) (165 aa)
      score_image score_image   score_image   0.715
MARCH11
membrane-associated ring finger (C3HC4) 11; E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids (By similarity) (402 aa)
        score_image   score_image   0.667
MARCH8
membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS (291 aa)
        score_image   score_image   0.667
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (808 aa)
        score_image   score_image   0.667
MARCH3
membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity) (253 aa)
        score_image   score_image   0.667
MARCH6
membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1 (910 aa)
        score_image   score_image   0.667
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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