| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATOH8 | BMP6 | ENSP00000304676 | ENSP00000283147 | atonal homolog 8 (Drosophila); Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity) | bone morphogenetic protein 6; Induces cartilage and bone formation | 0.703 |
| ATOH8 | GATA4 | ENSP00000304676 | ENSP00000334458 | atonal homolog 8 (Drosophila); Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity) | GATA binding protein 4; Transcriptional activator. Binds to the consensus sequence 5’-AGATAG-3’. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement | 0.800 |
| ATOH8 | GDF15 | ENSP00000304676 | ENSP00000252809 | atonal homolog 8 (Drosophila); Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity) | growth differentiation factor 15 | 0.415 |
| ATOH8 | HAMP | ENSP00000304676 | ENSP00000222304 | atonal homolog 8 (Drosophila); Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity) | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | 0.854 |
| ATOH8 | SMAD7 | ENSP00000304676 | ENSP00000262158 | atonal homolog 8 (Drosophila); Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity) | SMAD family member 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator ( [...] | 0.649 |
| ATOH8 | TFR2 | ENSP00000304676 | ENSP00000223051 | atonal homolog 8 (Drosophila); Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity) | transferrin receptor 2; Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation | 0.568 |
| ATOH8 | TMPRSS6 | ENSP00000304676 | ENSP00000334962 | atonal homolog 8 (Drosophila); Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity) | transmembrane protease, serine 6 | 0.583 |
| BMP6 | ATOH8 | ENSP00000283147 | ENSP00000304676 | bone morphogenetic protein 6; Induces cartilage and bone formation | atonal homolog 8 (Drosophila); Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity) | 0.703 |
| BMP6 | GATA4 | ENSP00000283147 | ENSP00000334458 | bone morphogenetic protein 6; Induces cartilage and bone formation | GATA binding protein 4; Transcriptional activator. Binds to the consensus sequence 5’-AGATAG-3’. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement | 0.793 |
| BMP6 | HAMP | ENSP00000283147 | ENSP00000222304 | bone morphogenetic protein 6; Induces cartilage and bone formation | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | 0.893 |
| BMP6 | SMAD7 | ENSP00000283147 | ENSP00000262158 | bone morphogenetic protein 6; Induces cartilage and bone formation | SMAD family member 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator ( [...] | 0.932 |
| BMP6 | TFR2 | ENSP00000283147 | ENSP00000223051 | bone morphogenetic protein 6; Induces cartilage and bone formation | transferrin receptor 2; Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation | 0.648 |
| BMP6 | TMPRSS6 | ENSP00000283147 | ENSP00000334962 | bone morphogenetic protein 6; Induces cartilage and bone formation | transmembrane protease, serine 6 | 0.921 |
| GATA4 | ATOH8 | ENSP00000334458 | ENSP00000304676 | GATA binding protein 4; Transcriptional activator. Binds to the consensus sequence 5’-AGATAG-3’. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement | atonal homolog 8 (Drosophila); Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity) | 0.800 |
| GATA4 | BMP6 | ENSP00000334458 | ENSP00000283147 | GATA binding protein 4; Transcriptional activator. Binds to the consensus sequence 5’-AGATAG-3’. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement | bone morphogenetic protein 6; Induces cartilage and bone formation | 0.793 |
| GDF15 | ATOH8 | ENSP00000252809 | ENSP00000304676 | growth differentiation factor 15 | atonal homolog 8 (Drosophila); Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity) | 0.415 |
| GDF15 | HAMP | ENSP00000252809 | ENSP00000222304 | growth differentiation factor 15 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | 0.865 |
| GDF15 | SMAD7 | ENSP00000252809 | ENSP00000262158 | growth differentiation factor 15 | SMAD family member 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator ( [...] | 0.454 |
| GDF15 | TFR2 | ENSP00000252809 | ENSP00000223051 | growth differentiation factor 15 | transferrin receptor 2; Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation | 0.508 |
| GDF15 | TMPRSS6 | ENSP00000252809 | ENSP00000334962 | growth differentiation factor 15 | transmembrane protease, serine 6 | 0.586 |
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