ELOVL6 protein (Homo sapiens) - STRING network view

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ELOVL6

ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs (265 aa)

Predicted Functional Partners:

SREBF2

0.933

SREBF1

0.907

SCD

0.838

OXSM

0.834

LCE3C

0.800

LCE3E

0.757

LCE3D

0.757

CERS2

0.757

LCE2D

0.750

LCE2C

0.750

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CERS2	ELOVL6	ENSP00000271688	ENSP00000304736	ceramide synthase 2; Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis	ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs	0.757
ELOVL6	CERS2	ENSP00000304736	ENSP00000271688	ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs	ceramide synthase 2; Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis	0.757
ELOVL6	LCE2C	ENSP00000304736	ENSP00000357772	ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs	late cornified envelope 2C; Precursors of the cornified envelope of the stratum	0.750
ELOVL6	LCE2D	ENSP00000304736	ENSP00000357773	ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs	late cornified envelope 2D; Precursors of the cornified envelope of the stratum corneum	0.750
ELOVL6	LCE3C	ENSP00000304736	ENSP00000334644	ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs	late cornified envelope 3C; Precursors of the cornified envelope of the stratum corneum	0.800
ELOVL6	LCE3D	ENSP00000304736	ENSP00000357776	ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs	late cornified envelope 3D; Precursors of the cornified envelope of the stratum corneum	0.757
ELOVL6	LCE3E	ENSP00000304736	ENSP00000357778	ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs	late cornified envelope 3E; Precursors of the cornified envelope of the stratum corneum	0.757
ELOVL6	OXSM	ENSP00000304736	ENSP00000280701	ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs	3-oxoacyl-ACP synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function	0.834
ELOVL6	SCD	ENSP00000304736	ENSP00000359380	ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs	stearoyl-CoA desaturase (delta-9-desaturase)	0.838
ELOVL6	SREBF1	ENSP00000304736	ENSP00000348069	ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs	sterol regulatory element binding transcription factor 1; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’). Has dual sequence specificity binding to both an E-box motif (5’-ATCACGTGA-3’) and to SRE-1 (5’-ATCACCCCAC-3’)	0.907
ELOVL6	SREBF2	ENSP00000304736	ENSP00000354476	ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs	sterol regulatory element binding transcription factor 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’) found in the flanking region of the LDRL and HMG-CoA synthase genes	0.933
LCE2C	ELOVL6	ENSP00000357772	ENSP00000304736	late cornified envelope 2C; Precursors of the cornified envelope of the stratum	ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs	0.750
LCE2C	LCE2D	ENSP00000357772	ENSP00000357773	late cornified envelope 2C; Precursors of the cornified envelope of the stratum	late cornified envelope 2D; Precursors of the cornified envelope of the stratum corneum	0.588
LCE2C	LCE3D	ENSP00000357772	ENSP00000357776	late cornified envelope 2C; Precursors of the cornified envelope of the stratum	late cornified envelope 3D; Precursors of the cornified envelope of the stratum corneum	0.501
LCE2D	ELOVL6	ENSP00000357773	ENSP00000304736	late cornified envelope 2D; Precursors of the cornified envelope of the stratum corneum	ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs	0.750
LCE2D	LCE2C	ENSP00000357773	ENSP00000357772	late cornified envelope 2D; Precursors of the cornified envelope of the stratum corneum	late cornified envelope 2C; Precursors of the cornified envelope of the stratum	0.588
LCE2D	LCE3C	ENSP00000357773	ENSP00000334644	late cornified envelope 2D; Precursors of the cornified envelope of the stratum corneum	late cornified envelope 3C; Precursors of the cornified envelope of the stratum corneum	0.472
LCE2D	LCE3D	ENSP00000357773	ENSP00000357776	late cornified envelope 2D; Precursors of the cornified envelope of the stratum corneum	late cornified envelope 3D; Precursors of the cornified envelope of the stratum corneum	0.506
LCE3C	ELOVL6	ENSP00000334644	ENSP00000304736	late cornified envelope 3C; Precursors of the cornified envelope of the stratum corneum	ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs	0.800
LCE3C	LCE2D	ENSP00000334644	ENSP00000357773	late cornified envelope 3C; Precursors of the cornified envelope of the stratum corneum	late cornified envelope 2D; Precursors of the cornified envelope of the stratum corneum	0.472

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