DTYMK protein (Homo sapiens) - STRING network view

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DTYMK

deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP (212 aa)

Predicted Functional Partners:

DUT

0.979

TYMS

0.978

NME4

0.972

TK1

0.969

DCTD

0.966

NME2

0.956

NME1

0.954

NME3

0.954

RRM1

0.954

NME1-NME2

0.954

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCTD	DTYMK	ENSP00000349576	ENSP00000304802	dCMP deaminase; Supplies the nucleotide substrate for thymidylate synthetase	deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP	0.966
DCTD	DUT	ENSP00000349576	ENSP00000370376	dCMP deaminase; Supplies the nucleotide substrate for thymidylate synthetase	deoxyuridine triphosphatase	0.970
DCTD	TK1	ENSP00000349576	ENSP00000301634	dCMP deaminase; Supplies the nucleotide substrate for thymidylate synthetase	thymidine kinase 1, soluble	0.950
DCTD	TYMS	ENSP00000349576	ENSP00000315644	dCMP deaminase; Supplies the nucleotide substrate for thymidylate synthetase	thymidylate synthetase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway	0.977
DTYMK	DCTD	ENSP00000304802	ENSP00000349576	deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP	dCMP deaminase; Supplies the nucleotide substrate for thymidylate synthetase	0.966
DTYMK	DUT	ENSP00000304802	ENSP00000370376	deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP	deoxyuridine triphosphatase	0.979
DTYMK	NME1	ENSP00000304802	ENSP00000013034	deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP	NME/NM23 nucleoside diphosphate kinase 1; Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3’-5’ exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination	0.954
DTYMK	NME1-NME2	ENSP00000304802	ENSP00000376886	deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP	NME1-NME2 readthrough; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)	0.954
DTYMK	NME2	ENSP00000304802	ENSP00000376889	deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP	NME/NM23 nucleoside diphosphate kinase 2; Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed-8392752). Exhibits histidine protein kinase activity	0.956
DTYMK	NME3	ENSP00000304802	ENSP00000219302	deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP	NME/NM23 nucleoside diphosphate kinase 3; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis	0.954
DTYMK	NME4	ENSP00000304802	ENSP00000219479	deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP	NME/NM23 nucleoside diphosphate kinase 4; Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity)	0.972
DTYMK	RRM1	ENSP00000304802	ENSP00000300738	deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP	ribonucleotide reductase M1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)	0.954
DTYMK	TK1	ENSP00000304802	ENSP00000301634	deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP	thymidine kinase 1, soluble	0.969
DTYMK	TYMS	ENSP00000304802	ENSP00000315644	deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP	thymidylate synthetase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway	0.978
DUT	DCTD	ENSP00000370376	ENSP00000349576	deoxyuridine triphosphatase	dCMP deaminase; Supplies the nucleotide substrate for thymidylate synthetase	0.970
DUT	DTYMK	ENSP00000370376	ENSP00000304802	deoxyuridine triphosphatase	deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP	0.979
DUT	NME1	ENSP00000370376	ENSP00000013034	deoxyuridine triphosphatase	NME/NM23 nucleoside diphosphate kinase 1; Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3’-5’ exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination	0.929
DUT	NME1-NME2	ENSP00000370376	ENSP00000376886	deoxyuridine triphosphatase	NME1-NME2 readthrough; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)	0.932
DUT	NME2	ENSP00000370376	ENSP00000376889	deoxyuridine triphosphatase	NME/NM23 nucleoside diphosphate kinase 2; Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed-8392752). Exhibits histidine protein kinase activity	0.935
DUT	NME3	ENSP00000370376	ENSP00000219302	deoxyuridine triphosphatase	NME/NM23 nucleoside diphosphate kinase 3; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis	0.923

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