| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMELX | ZFX | ENSP00000370088 | ENSP00000304985 | amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel | zinc finger protein, X-linked; Probable transcriptional activator | 0.607 |
| AMELY | SRY | ENSP00000215479 | ENSP00000372547 | amelogenin, Y-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel | sex determining region Y; Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial interc [...] | 0.555 |
| AMELY | ZFX | ENSP00000215479 | ENSP00000304985 | amelogenin, Y-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel | zinc finger protein, X-linked; Probable transcriptional activator | 0.662 |
| CETN3 | ZFX | ENSP00000283122 | ENSP00000304985 | centrin, EF-hand protein, 3; Plays a fundamental role in microtubule-organizing center structure and function | zinc finger protein, X-linked; Probable transcriptional activator | 0.657 |
| KDM6A | RNF111 | ENSP00000367203 | ENSP00000288199 | lysine (K)-specific demethylase 6A; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of ’Lys-27’ of histone H3 is concomitant with methylation of ’Lys-4’ of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A | ring finger protein 111 | 0.526 |
| KDM6A | SRY | ENSP00000367203 | ENSP00000372547 | lysine (K)-specific demethylase 6A; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of ’Lys-27’ of histone H3 is concomitant with methylation of ’Lys-4’ of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A | sex determining region Y; Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial interc [...] | 0.769 |
| KDM6A | ZFX | ENSP00000367203 | ENSP00000304985 | lysine (K)-specific demethylase 6A; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of ’Lys-27’ of histone H3 is concomitant with methylation of ’Lys-4’ of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A | zinc finger protein, X-linked; Probable transcriptional activator | 0.644 |
| MEA1 | SRY | ENSP00000244711 | ENSP00000372547 | male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | sex determining region Y; Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial interc [...] | 0.403 |
| MEA1 | ZFX | ENSP00000244711 | ENSP00000304985 | male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | zinc finger protein, X-linked; Probable transcriptional activator | 0.659 |
| NR1I2 | RNF111 | ENSP00000336528 | ENSP00000288199 | nuclear receptor subfamily 1, group I, member 2 | ring finger protein 111 | 0.514 |
| NR1I2 | SRY | ENSP00000336528 | ENSP00000372547 | nuclear receptor subfamily 1, group I, member 2 | sex determining region Y; Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial interc [...] | 0.440 |
| NR1I2 | UBA1 | ENSP00000336528 | ENSP00000338413 | nuclear receptor subfamily 1, group I, member 2 | ubiquitin-like modifier activating enzyme 1; Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP | 0.501 |
| NR1I2 | ZFX | ENSP00000336528 | ENSP00000304985 | nuclear receptor subfamily 1, group I, member 2 | zinc finger protein, X-linked; Probable transcriptional activator | 0.697 |
| POLA1 | ZFX | ENSP00000368349 | ENSP00000304985 | polymerase (DNA directed), alpha 1, catalytic subunit; Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by [...] | zinc finger protein, X-linked; Probable transcriptional activator | 0.753 |
| RNF111 | KDM6A | ENSP00000288199 | ENSP00000367203 | ring finger protein 111 | lysine (K)-specific demethylase 6A; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of ’Lys-27’ of histone H3 is concomitant with methylation of ’Lys-4’ of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A | 0.526 |
| RNF111 | NR1I2 | ENSP00000288199 | ENSP00000336528 | ring finger protein 111 | nuclear receptor subfamily 1, group I, member 2 | 0.514 |
| RNF111 | UBA1 | ENSP00000288199 | ENSP00000338413 | ring finger protein 111 | ubiquitin-like modifier activating enzyme 1; Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP | 0.466 |
| RNF111 | ZFX | ENSP00000288199 | ENSP00000304985 | ring finger protein 111 | zinc finger protein, X-linked; Probable transcriptional activator | 0.651 |
| SRY | AMELY | ENSP00000372547 | ENSP00000215479 | sex determining region Y; Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial interc [...] | amelogenin, Y-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel | 0.555 |
| SRY | KDM6A | ENSP00000372547 | ENSP00000367203 | sex determining region Y; Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial interc [...] | lysine (K)-specific demethylase 6A; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of ’Lys-27’ of histone H3 is concomitant with methylation of ’Lys-4’ of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A | 0.769 |
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