HS1BP3 protein (Homo sapiens) - STRING network view

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HS1BP3

HCLS1 binding protein 3; May be a modulator of IL-2 signaling (By similarity) (392 aa)

Predicted Functional Partners:

DRD3

0.757

TOR1A

0.608

SNX18

0.604

HCLS1

0.576

JMJD6

0.575

BRD4

0.575

LINGO1

0.560

TPH1

0.560

CCDC90A

0.509

YWHAZ

0.493

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRD4	HS1BP3	ENSP00000263377	ENSP00000305193	bromodomain containing 4; Plays a role in a process governing chromosomal dynamics during mitosis (By similarity)	HCLS1 binding protein 3; May be a modulator of IL-2 signaling (By similarity)	0.575
BRD4	JMJD6	ENSP00000263377	ENSP00000394085	bromodomain containing 4; Plays a role in a process governing chromosomal dynamics during mitosis (By similarity)	jumonji domain containing 6; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates [...]	0.624
BRD4	YWHAZ	ENSP00000263377	ENSP00000309503	bromodomain containing 4; Plays a role in a process governing chromosomal dynamics during mitosis (By similarity)	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.487
CCDC90A	HS1BP3	ENSP00000368468	ENSP00000305193	coiled-coil domain containing 90A; Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake, possibly via a direct interaction with MCU	HCLS1 binding protein 3; May be a modulator of IL-2 signaling (By similarity)	0.509
DRD3	HS1BP3	ENSP00000373169	ENSP00000305193	dopamine receptor D3; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation	HCLS1 binding protein 3; May be a modulator of IL-2 signaling (By similarity)	0.757
DRD3	LINGO1	ENSP00000373169	ENSP00000347451	dopamine receptor D3; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation	leucine rich repeat and Ig domain containing 1	0.660
HCLS1	HS1BP3	ENSP00000320176	ENSP00000305193	hematopoietic cell-specific Lyn substrate 1; Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression	HCLS1 binding protein 3; May be a modulator of IL-2 signaling (By similarity)	0.576
HS1BP3	BRD4	ENSP00000305193	ENSP00000263377	HCLS1 binding protein 3; May be a modulator of IL-2 signaling (By similarity)	bromodomain containing 4; Plays a role in a process governing chromosomal dynamics during mitosis (By similarity)	0.575
HS1BP3	CCDC90A	ENSP00000305193	ENSP00000368468	HCLS1 binding protein 3; May be a modulator of IL-2 signaling (By similarity)	coiled-coil domain containing 90A; Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake, possibly via a direct interaction with MCU	0.509
HS1BP3	DRD3	ENSP00000305193	ENSP00000373169	HCLS1 binding protein 3; May be a modulator of IL-2 signaling (By similarity)	dopamine receptor D3; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation	0.757
HS1BP3	HCLS1	ENSP00000305193	ENSP00000320176	HCLS1 binding protein 3; May be a modulator of IL-2 signaling (By similarity)	hematopoietic cell-specific Lyn substrate 1; Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression	0.576
HS1BP3	JMJD6	ENSP00000305193	ENSP00000394085	HCLS1 binding protein 3; May be a modulator of IL-2 signaling (By similarity)	jumonji domain containing 6; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates [...]	0.575
HS1BP3	LINGO1	ENSP00000305193	ENSP00000347451	HCLS1 binding protein 3; May be a modulator of IL-2 signaling (By similarity)	leucine rich repeat and Ig domain containing 1	0.560
HS1BP3	SNX18	ENSP00000305193	ENSP00000317332	HCLS1 binding protein 3; May be a modulator of IL-2 signaling (By similarity)	sorting nexin 18; May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane	0.604
HS1BP3	TOR1A	ENSP00000305193	ENSP00000345719	HCLS1 binding protein 3; May be a modulator of IL-2 signaling (By similarity)	torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged	0.608
HS1BP3	TPH1	ENSP00000305193	ENSP00000250018	HCLS1 binding protein 3; May be a modulator of IL-2 signaling (By similarity)	tryptophan hydroxylase 1	0.560
HS1BP3	YWHAZ	ENSP00000305193	ENSP00000309503	HCLS1 binding protein 3; May be a modulator of IL-2 signaling (By similarity)	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.493
JMJD6	BRD4	ENSP00000394085	ENSP00000263377	jumonji domain containing 6; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates [...]	bromodomain containing 4; Plays a role in a process governing chromosomal dynamics during mitosis (By similarity)	0.624
JMJD6	HS1BP3	ENSP00000394085	ENSP00000305193	jumonji domain containing 6; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates [...]	HCLS1 binding protein 3; May be a modulator of IL-2 signaling (By similarity)	0.575
LINGO1	DRD3	ENSP00000347451	ENSP00000373169	leucine rich repeat and Ig domain containing 1	dopamine receptor D3; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation	0.660

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