| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARX | IL1RAPL1 | ENSP00000368332 | ENSP00000305200 | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | interleukin 1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons | 0.680 |
| ARX | VCX | ENSP00000368332 | ENSP00000370447 | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | variable charge, X-linked; May mediate a process in spermatogenesis or may play a role in sex ratio distortion | 0.680 |
| ARX | VCX2 | ENSP00000368332 | ENSP00000321309 | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | variable charge, X-linked 2; May mediate a process in spermatogenesis or may play a role in sex ratio distortion | 0.680 |
| ARX | VCX3A | ENSP00000368332 | ENSP00000370479 | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | variable charge, X-linked 3A; May mediate a process in spermatogenesis or may play a role in sex ratio distortion | 0.519 |
| ARX | VCX3B | ENSP00000368332 | ENSP00000370420 | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | variable charge, X-linked 3B; May mediate a process in spermatogenesis or may play a role in sex ratio distortion | 0.680 |
| CADPS | IL1RAPL1 | ENSP00000373215 | ENSP00000305200 | Ca++-dependent secretion activator; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small [...] | interleukin 1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons | 0.607 |
| CADPS | PI4KB | ENSP00000373215 | ENSP00000271657 | Ca++-dependent secretion activator; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small [...] | phosphatidylinositol 4-kinase, catalytic, beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) | 0.801 |
| CADPS | VSNL1 | ENSP00000373215 | ENSP00000295156 | Ca++-dependent secretion activator; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small [...] | visinin-like 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner (By similarity) | 0.681 |
| GK | IL1RAPL1 | ENSP00000368226 | ENSP00000305200 | glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism | interleukin 1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons | 0.658 |
| IL1RAPL1 | ARX | ENSP00000305200 | ENSP00000368332 | interleukin 1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons | aristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate | 0.680 |
| IL1RAPL1 | CADPS | ENSP00000305200 | ENSP00000373215 | interleukin 1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons | Ca++-dependent secretion activator; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small [...] | 0.607 |
| IL1RAPL1 | GK | ENSP00000305200 | ENSP00000368226 | interleukin 1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons | glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism | 0.658 |
| IL1RAPL1 | PI4KB | ENSP00000305200 | ENSP00000271657 | interleukin 1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons | phosphatidylinositol 4-kinase, catalytic, beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) | 0.609 |
| IL1RAPL1 | PTPRF | ENSP00000305200 | ENSP00000353030 | interleukin 1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons | protein tyrosine phosphatase, receptor type, F; Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) | 0.816 |
| IL1RAPL1 | VCX | ENSP00000305200 | ENSP00000370447 | interleukin 1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons | variable charge, X-linked; May mediate a process in spermatogenesis or may play a role in sex ratio distortion | 0.745 |
| IL1RAPL1 | VCX2 | ENSP00000305200 | ENSP00000321309 | interleukin 1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons | variable charge, X-linked 2; May mediate a process in spermatogenesis or may play a role in sex ratio distortion | 0.745 |
| IL1RAPL1 | VCX3A | ENSP00000305200 | ENSP00000370479 | interleukin 1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons | variable charge, X-linked 3A; May mediate a process in spermatogenesis or may play a role in sex ratio distortion | 0.608 |
| IL1RAPL1 | VCX3B | ENSP00000305200 | ENSP00000370420 | interleukin 1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons | variable charge, X-linked 3B; May mediate a process in spermatogenesis or may play a role in sex ratio distortion | 0.745 |
| IL1RAPL1 | VSNL1 | ENSP00000305200 | ENSP00000295156 | interleukin 1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons | visinin-like 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner (By similarity) | 0.610 |
| PI4KB | CADPS | ENSP00000271657 | ENSP00000373215 | phosphatidylinositol 4-kinase, catalytic, beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) | Ca++-dependent secretion activator; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small [...] | 0.801 |
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