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STRINGSTRING
FSBP FSBP CEP55 CEP55 CKAP2L CKAP2L CCDC34 CCDC34 UBC UBC CDCA5 CDCA5 SPC24 SPC24 CASC5 CASC5 SPDL1 SPDL1
"CKAP2L" - cytoskeleton associated protein 2-like in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
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experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
CKAP2Lcytoskeleton associated protein 2-like (745 aa)    
Predicted Functional Partners:
CASC5
cancer susceptibility candidate 5; Performs two crucial functions during mitosis- it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (2342 aa)
      score_image     score_image   0.492
FSBP
fibrinogen silencer binding protein; Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1 (299 aa)
            score_image   0.485
UBC
ubiquitin C (685 aa)
        score_image       0.483
SPC24
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae); Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (197 aa)
      score_image     score_image   0.437
CDCA5
cell division cycle associated 5; Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair (252 aa)
      score_image     score_image   0.433
CEP55
centrosomal protein 55kDa; Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis (464 aa)
      score_image     score_image   0.424
SPDL1
spindle apparatus coiled-coil protein 1; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (605 aa)
      score_image     score_image   0.419
CCDC34
coiled-coil domain containing 34 (373 aa)
            score_image   0.414
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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