node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASC5 | CDCA5 | ENSP00000335463 | ENSP00000275517 | cancer susceptibility candidate 5; Performs two crucial functions during mitosis- it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore | cell division cycle associated 5; Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair | 0.924 |
CASC5 | CKAP2L | ENSP00000335463 | ENSP00000305204 | cancer susceptibility candidate 5; Performs two crucial functions during mitosis- it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore | cytoskeleton associated protein 2-like | 0.492 |
CASC5 | SPC24 | ENSP00000335463 | ENSP00000465075 | cancer susceptibility candidate 5; Performs two crucial functions during mitosis- it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore | SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae); Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore | 0.942 |
CASC5 | SPDL1 | ENSP00000335463 | ENSP00000265295 | cancer susceptibility candidate 5; Performs two crucial functions during mitosis- it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore | spindle apparatus coiled-coil protein 1; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment | 0.928 |
CASC5 | UBC | ENSP00000335463 | ENSP00000344818 | cancer susceptibility candidate 5; Performs two crucial functions during mitosis- it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore | ubiquitin C | 0.795 |
CCDC34 | CKAP2L | ENSP00000330240 | ENSP00000305204 | coiled-coil domain containing 34 | cytoskeleton associated protein 2-like | 0.414 |
CDCA5 | CASC5 | ENSP00000275517 | ENSP00000335463 | cell division cycle associated 5; Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair | cancer susceptibility candidate 5; Performs two crucial functions during mitosis- it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore | 0.924 |
CDCA5 | CEP55 | ENSP00000275517 | ENSP00000360540 | cell division cycle associated 5; Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair | centrosomal protein 55kDa; Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis | 0.414 |
CDCA5 | CKAP2L | ENSP00000275517 | ENSP00000305204 | cell division cycle associated 5; Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair | cytoskeleton associated protein 2-like | 0.433 |
CDCA5 | SPC24 | ENSP00000275517 | ENSP00000465075 | cell division cycle associated 5; Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair | SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae); Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore | 0.952 |
CDCA5 | SPDL1 | ENSP00000275517 | ENSP00000265295 | cell division cycle associated 5; Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair | spindle apparatus coiled-coil protein 1; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment | 0.926 |
CEP55 | CDCA5 | ENSP00000360540 | ENSP00000275517 | centrosomal protein 55kDa; Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis | cell division cycle associated 5; Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair | 0.414 |
CEP55 | CKAP2L | ENSP00000360540 | ENSP00000305204 | centrosomal protein 55kDa; Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis | cytoskeleton associated protein 2-like | 0.424 |
CEP55 | UBC | ENSP00000360540 | ENSP00000344818 | centrosomal protein 55kDa; Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis | ubiquitin C | 0.795 |
CKAP2L | CASC5 | ENSP00000305204 | ENSP00000335463 | cytoskeleton associated protein 2-like | cancer susceptibility candidate 5; Performs two crucial functions during mitosis- it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore | 0.492 |
CKAP2L | CCDC34 | ENSP00000305204 | ENSP00000330240 | cytoskeleton associated protein 2-like | coiled-coil domain containing 34 | 0.414 |
CKAP2L | CDCA5 | ENSP00000305204 | ENSP00000275517 | cytoskeleton associated protein 2-like | cell division cycle associated 5; Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair | 0.433 |
CKAP2L | CEP55 | ENSP00000305204 | ENSP00000360540 | cytoskeleton associated protein 2-like | centrosomal protein 55kDa; Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis | 0.424 |
CKAP2L | FSBP | ENSP00000305204 | ENSP00000420405 | cytoskeleton associated protein 2-like | fibrinogen silencer binding protein; Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1 | 0.485 |
CKAP2L | SPC24 | ENSP00000305204 | ENSP00000465075 | cytoskeleton associated protein 2-like | SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae); Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore | 0.437 |