SOX14 protein (Homo sapiens) - STRING network view

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SOX14

SRY (sex determining region Y)-box 14; Acts as a negative regulator of transcription (By similarity) (240 aa)

Predicted Functional Partners:

FOXA2

0.832

NAIF1

0.612

FOXL2

0.610

ESYT3

0.499

NEUROG2

0.430

GBX2

0.414

NKX2-2

0.407

DZIP1L

0.405

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DZIP1L	ESYT3	ENSP00000332148	ENSP00000374218	DAZ interacting protein 1-like	extended synaptotagmin-like protein 3; May play a role as calcium-regulated intrinsic membrane protein (By similarity)	0.472
DZIP1L	SOX14	ENSP00000332148	ENSP00000305343	DAZ interacting protein 1-like	SRY (sex determining region Y)-box 14; Acts as a negative regulator of transcription (By similarity)	0.405
ESYT3	DZIP1L	ENSP00000374218	ENSP00000332148	extended synaptotagmin-like protein 3; May play a role as calcium-regulated intrinsic membrane protein (By similarity)	DAZ interacting protein 1-like	0.472
ESYT3	SOX14	ENSP00000374218	ENSP00000305343	extended synaptotagmin-like protein 3; May play a role as calcium-regulated intrinsic membrane protein (By similarity)	SRY (sex determining region Y)-box 14; Acts as a negative regulator of transcription (By similarity)	0.499
FOXA2	GBX2	ENSP00000315955	ENSP00000302251	forkhead box A2; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). In embryonic development is required for notochord formation. Involved in the devel [...]	gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo	0.400
FOXA2	NKX2-2	ENSP00000315955	ENSP00000366347	forkhead box A2; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). In embryonic development is required for notochord formation. Involved in the devel [...]	NK2 homeobox 2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity)	0.980
FOXA2	SOX14	ENSP00000315955	ENSP00000305343	forkhead box A2; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). In embryonic development is required for notochord formation. Involved in the devel [...]	SRY (sex determining region Y)-box 14; Acts as a negative regulator of transcription (By similarity)	0.832
FOXL2	SOX14	ENSP00000333188	ENSP00000305343	forkhead box L2; Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans- differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-bi [...]	SRY (sex determining region Y)-box 14; Acts as a negative regulator of transcription (By similarity)	0.610
GBX2	FOXA2	ENSP00000302251	ENSP00000315955	gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo	forkhead box A2; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). In embryonic development is required for notochord formation. Involved in the devel [...]	0.400
GBX2	NEUROG2	ENSP00000302251	ENSP00000317333	gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo	neurogenin 2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’)	0.515
GBX2	SOX14	ENSP00000302251	ENSP00000305343	gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo	SRY (sex determining region Y)-box 14; Acts as a negative regulator of transcription (By similarity)	0.414
NAIF1	SOX14	ENSP00000362170	ENSP00000305343	nuclear apoptosis inducing factor 1; Induces apoptosis	SRY (sex determining region Y)-box 14; Acts as a negative regulator of transcription (By similarity)	0.612
NEUROG2	GBX2	ENSP00000317333	ENSP00000302251	neurogenin 2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’)	gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo	0.515
NEUROG2	NKX2-2	ENSP00000317333	ENSP00000366347	neurogenin 2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’)	NK2 homeobox 2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity)	0.648
NEUROG2	SOX14	ENSP00000317333	ENSP00000305343	neurogenin 2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’)	SRY (sex determining region Y)-box 14; Acts as a negative regulator of transcription (By similarity)	0.430
NKX2-2	FOXA2	ENSP00000366347	ENSP00000315955	NK2 homeobox 2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity)	forkhead box A2; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). In embryonic development is required for notochord formation. Involved in the devel [...]	0.980
NKX2-2	NEUROG2	ENSP00000366347	ENSP00000317333	NK2 homeobox 2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity)	neurogenin 2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’)	0.648
NKX2-2	SOX14	ENSP00000366347	ENSP00000305343	NK2 homeobox 2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity)	SRY (sex determining region Y)-box 14; Acts as a negative regulator of transcription (By similarity)	0.407
SOX14	DZIP1L	ENSP00000305343	ENSP00000332148	SRY (sex determining region Y)-box 14; Acts as a negative regulator of transcription (By similarity)	DAZ interacting protein 1-like	0.405
SOX14	ESYT3	ENSP00000305343	ENSP00000374218	SRY (sex determining region Y)-box 14; Acts as a negative regulator of transcription (By similarity)	extended synaptotagmin-like protein 3; May play a role as calcium-regulated intrinsic membrane protein (By similarity)	0.499

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