CNNM3 protein (Homo sapiens) - STRING network view

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Score

CNNM3

cyclin M3; Probable metal transporter (By similarity) (707 aa)

Predicted Functional Partners:

UBC

0.924

HPSE2

0.757

CRABP2

0.748

FNDC3A

0.658

BACE1

0.581

FAM178B

0.570

ILK

0.554

YBEY

0.552

CABLES2

0.545

FAHD2B

0.534

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BACE1	CNNM3	ENSP00000318585	ENSP00000305449	beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase	cyclin M3; Probable metal transporter (By similarity)	0.581
BACE1	UBC	ENSP00000318585	ENSP00000344818	beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase	ubiquitin C	0.667
CABLES2	CNNM3	ENSP00000279101	ENSP00000305449	Cdk5 and Abl enzyme substrate 2; Unknown. Probably involved in G1-S cell cycle transition	cyclin M3; Probable metal transporter (By similarity)	0.545
CNNM3	BACE1	ENSP00000305449	ENSP00000318585	cyclin M3; Probable metal transporter (By similarity)	beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase	0.581
CNNM3	CABLES2	ENSP00000305449	ENSP00000279101	cyclin M3; Probable metal transporter (By similarity)	Cdk5 and Abl enzyme substrate 2; Unknown. Probably involved in G1-S cell cycle transition	0.545
CNNM3	CRABP2	ENSP00000305449	ENSP00000357204	cyclin M3; Probable metal transporter (By similarity)	cellular retinoic acid binding protein 2; Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors	0.748
CNNM3	FAHD2B	ENSP00000305449	ENSP00000272610	cyclin M3; Probable metal transporter (By similarity)	fumarylacetoacetate hydrolase domain containing 2B; May have hydrolase activity (By similarity)	0.534
CNNM3	FAM178B	ENSP00000305449	ENSP00000429896	cyclin M3; Probable metal transporter (By similarity)	family with sequence similarity 178, member B	0.570
CNNM3	FNDC3A	ENSP00000305449	ENSP00000417257	cyclin M3; Probable metal transporter (By similarity)	fibronectin type III domain containing 3A	0.658
CNNM3	HPSE2	ENSP00000305449	ENSP00000359583	cyclin M3; Probable metal transporter (By similarity)	heparanase 2; Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro)	0.757
CNNM3	ILK	ENSP00000305449	ENSP00000299421	cyclin M3; Probable metal transporter (By similarity)	integrin-linked kinase; Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B	0.554
CNNM3	UBC	ENSP00000305449	ENSP00000344818	cyclin M3; Probable metal transporter (By similarity)	ubiquitin C	0.924
CNNM3	YBEY	ENSP00000305449	ENSP00000329614	cyclin M3; Probable metal transporter (By similarity)	ybeY metallopeptidase (putative)	0.552
CRABP2	CNNM3	ENSP00000357204	ENSP00000305449	cellular retinoic acid binding protein 2; Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors	cyclin M3; Probable metal transporter (By similarity)	0.748
CRABP2	FNDC3A	ENSP00000357204	ENSP00000417257	cellular retinoic acid binding protein 2; Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors	fibronectin type III domain containing 3A	0.748
CRABP2	HPSE2	ENSP00000357204	ENSP00000359583	cellular retinoic acid binding protein 2; Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors	heparanase 2; Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro)	0.860
CRABP2	UBC	ENSP00000357204	ENSP00000344818	cellular retinoic acid binding protein 2; Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors	ubiquitin C	0.883
FAHD2B	CNNM3	ENSP00000272610	ENSP00000305449	fumarylacetoacetate hydrolase domain containing 2B; May have hydrolase activity (By similarity)	cyclin M3; Probable metal transporter (By similarity)	0.534
FAHD2B	FAM178B	ENSP00000272610	ENSP00000429896	fumarylacetoacetate hydrolase domain containing 2B; May have hydrolase activity (By similarity)	family with sequence similarity 178, member B	0.755
FAHD2B	UBC	ENSP00000272610	ENSP00000344818	fumarylacetoacetate hydrolase domain containing 2B; May have hydrolase activity (By similarity)	ubiquitin C	0.500

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