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HMCN1 HMCN1 CGB8 CGB8 VWF VWF CGA CGA VEGFA VEGFA SIRPG SIRPG ERBB4 ERBB4 F3 F3 SIRPB1 SIRPB1 CD276 CD276 CD47 CD47
"SIRPG" - signal-regulatory protein gamma in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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second shell of interactors
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experimentally determined
Predicted Interactions
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protein homology
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Score
SIRPGsignal-regulatory protein gamma; Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T- cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation (387 aa)    
Predicted Functional Partners:
CD47
CD47 molecule; Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integr [...] (323 aa)
        score_image score_image score_image   0.997
CGB8
chorionic gonadotropin, beta polypeptide 8 (165 aa)
        score_image       0.996
CGA
glycoprotein hormones, alpha polypeptide (116 aa)
        score_image       0.996
HMCN1
hemicentin 1 (5635 aa)
        score_image       0.992
SIRPB1
signal-regulatory protein beta 1; Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK (398 aa)
        score_image   score_image score_image 0.983
VEGFA
vascular endothelial growth factor A (412 aa)
        score_image       0.963
ERBB4
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest c [...] (1308 aa)
        score_image       0.963
F3
coagulation factor III (thromboplastin, tissue factor); Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF-VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade (295 aa)
        score_image       0.962
VWF
von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (2813 aa)
        score_image       0.917
CD276
CD276 molecule; May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modula [...] (534 aa)
        score_image       0.914
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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