GAA protein (Homo sapiens) - STRING network view

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GAA

glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes (952 aa)

Predicted Functional Partners:

AGA

0.943

GGT1

0.941

HES1

0.938

KLRP

0.923

YY1

0.921

AGL

0.912

HK1

0.911

HK3

0.910

HK2

0.907

SI

0.906

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGA	GAA	ENSP00000264595	ENSP00000305692	aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins	glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes	0.943
AGA	GGT1	ENSP00000264595	ENSP00000248923	aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins	gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive	0.925
AGL	GAA	ENSP00000294724	ENSP00000305692	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes	0.912
AGL	SI	ENSP00000294724	ENSP00000264382	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	sucrase-isomaltase (alpha-glucosidase); Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides	0.905
GAA	AGA	ENSP00000305692	ENSP00000264595	glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes	aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins	0.943
GAA	AGL	ENSP00000305692	ENSP00000294724	glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	0.912
GAA	GGT1	ENSP00000305692	ENSP00000248923	glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes	gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive	0.941
GAA	HES1	ENSP00000305692	ENSP00000232424	glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes	hairy and enhancer of split 1, (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs- 5’-CACNAG-3’ with high affinity and on E-box motifs- 5’-CANNTG-3’ with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage	0.938
GAA	HK1	ENSP00000305692	ENSP00000384774	glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes	hexokinase 1	0.911
GAA	HK2	ENSP00000305692	ENSP00000290573	glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes	hexokinase 2	0.907
GAA	HK3	ENSP00000305692	ENSP00000292432	glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes	hexokinase 3 (white cell)	0.910
GAA	KLRP	ENSP00000305692	ENSP00000471024	glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes	glucosidase, beta, acid 3 (cytosolic) (EC-3.2.1.21)	0.923
GAA	SI	ENSP00000305692	ENSP00000264382	glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes	sucrase-isomaltase (alpha-glucosidase); Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides	0.906
GAA	YY1	ENSP00000305692	ENSP00000262238	glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes	YY1 transcription factor; Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5’-CCGCCATNTT-3’; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repre [...]	0.921
GGT1	AGA	ENSP00000248923	ENSP00000264595	gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive	aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins	0.925
GGT1	GAA	ENSP00000248923	ENSP00000305692	gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive	glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes	0.941
GGT1	SI	ENSP00000248923	ENSP00000264382	gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive	sucrase-isomaltase (alpha-glucosidase); Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides	0.464
HES1	GAA	ENSP00000232424	ENSP00000305692	hairy and enhancer of split 1, (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs- 5’-CACNAG-3’ with high affinity and on E-box motifs- 5’-CANNTG-3’ with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage	glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes	0.938
HES1	SI	ENSP00000232424	ENSP00000264382	hairy and enhancer of split 1, (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs- 5’-CACNAG-3’ with high affinity and on E-box motifs- 5’-CANNTG-3’ with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage	sucrase-isomaltase (alpha-glucosidase); Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides	0.408
HES1	YY1	ENSP00000232424	ENSP00000262238	hairy and enhancer of split 1, (Drosophila); Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs- 5’-CACNAG-3’ with high affinity and on E-box motifs- 5’-CANNTG-3’ with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage	YY1 transcription factor; Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5’-CCGCCATNTT-3’; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repre [...]	0.650

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