node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS14 | BMP1 | ENSP00000362304 | ENSP00000305714 | ADAM metallopeptidase with thrombospondin type 1 motif, 14; Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity | bone morphogenetic protein 1 | 0.944 |
ADAMTS2 | BMP1 | ENSP00000251582 | ENSP00000305714 | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | bone morphogenetic protein 1 | 0.941 |
ADAMTS2 | COL7A1 | ENSP00000251582 | ENSP00000332371 | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | collagen, type VII, alpha 1; Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen | 0.440 |
ADAMTS2 | LOX | ENSP00000251582 | ENSP00000231004 | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | 0.548 |
BMP1 | ADAMTS14 | ENSP00000305714 | ENSP00000362304 | bone morphogenetic protein 1 | ADAM metallopeptidase with thrombospondin type 1 motif, 14; Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity | 0.944 |
BMP1 | ADAMTS2 | ENSP00000305714 | ENSP00000251582 | bone morphogenetic protein 1 | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | 0.941 |
BMP1 | CHRD | ENSP00000305714 | ENSP00000204604 | bone morphogenetic protein 1 | chordin | 0.996 |
BMP1 | COL7A1 | ENSP00000305714 | ENSP00000332371 | bone morphogenetic protein 1 | collagen, type VII, alpha 1; Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen | 0.966 |
BMP1 | HSPG2 | ENSP00000305714 | ENSP00000363827 | bone morphogenetic protein 1 | heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development | 0.973 |
BMP1 | LAMA3 | ENSP00000305714 | ENSP00000324532 | bone morphogenetic protein 1 | laminin, alpha 3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.972 |
BMP1 | LAMB3 | ENSP00000305714 | ENSP00000348384 | bone morphogenetic protein 1 | laminin, beta 3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.963 |
BMP1 | LAMC2 | ENSP00000305714 | ENSP00000264144 | bone morphogenetic protein 1 | laminin, gamma 2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell- scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells | 0.970 |
BMP1 | LOX | ENSP00000305714 | ENSP00000231004 | bone morphogenetic protein 1 | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | 0.962 |
BMP1 | PRL | ENSP00000305714 | ENSP00000302150 | bone morphogenetic protein 1 | prolactin; Prolactin acts primarily on the mammary gland by promoting lactation | 0.948 |
CHRD | BMP1 | ENSP00000204604 | ENSP00000305714 | chordin | bone morphogenetic protein 1 | 0.996 |
CHRD | LAMA3 | ENSP00000204604 | ENSP00000324532 | chordin | laminin, alpha 3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.418 |
COL7A1 | ADAMTS2 | ENSP00000332371 | ENSP00000251582 | collagen, type VII, alpha 1; Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | 0.440 |
COL7A1 | BMP1 | ENSP00000332371 | ENSP00000305714 | collagen, type VII, alpha 1; Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen | bone morphogenetic protein 1 | 0.966 |
COL7A1 | LAMA3 | ENSP00000332371 | ENSP00000324532 | collagen, type VII, alpha 1; Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen | laminin, alpha 3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.943 |
COL7A1 | LAMB3 | ENSP00000332371 | ENSP00000348384 | collagen, type VII, alpha 1; Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen | laminin, beta 3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.981 |