| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COMTD1 | LRTOMT | ENSP00000361616 | ENSP00000305742 | catechol-O-methyltransferase domain containing 1; Putative O-methyltransferase (Potential) | leucine rich transmembrane and 0-methyltransferase domain containing; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function | 0.450 |
| CTTN | LRTOMT | ENSP00000365745 | ENSP00000305742 | cortactin; Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases | leucine rich transmembrane and 0-methyltransferase domain containing; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function | 0.528 |
| CTTN | ORAOV1 | ENSP00000365745 | ENSP00000279147 | cortactin; Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases | oral cancer overexpressed 1 | 0.661 |
| CTTN | PPFIA1 | ENSP00000365745 | ENSP00000253925 | cortactin; Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates | 0.494 |
| CTTN | SHANK2 | ENSP00000365745 | ENSP00000345193 | cortactin; Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases | SH3 and multiple ankyrin repeat domains 2; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction | 0.970 |
| KCNE3 | LRTOMT | ENSP00000310557 | ENSP00000305742 | potassium voltage-gated channel, Isk-related family, member 3; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion | leucine rich transmembrane and 0-methyltransferase domain containing; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function | 0.689 |
| KCNE3 | SHANK2 | ENSP00000310557 | ENSP00000345193 | potassium voltage-gated channel, Isk-related family, member 3; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion | SH3 and multiple ankyrin repeat domains 2; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction | 0.681 |
| LRTOMT | COMTD1 | ENSP00000305742 | ENSP00000361616 | leucine rich transmembrane and 0-methyltransferase domain containing; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function | catechol-O-methyltransferase domain containing 1; Putative O-methyltransferase (Potential) | 0.450 |
| LRTOMT | CTTN | ENSP00000305742 | ENSP00000365745 | leucine rich transmembrane and 0-methyltransferase domain containing; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function | cortactin; Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases | 0.528 |
| LRTOMT | KCNE3 | ENSP00000305742 | ENSP00000310557 | leucine rich transmembrane and 0-methyltransferase domain containing; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function | potassium voltage-gated channel, Isk-related family, member 3; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion | 0.689 |
| LRTOMT | ORAOV1 | ENSP00000305742 | ENSP00000279147 | leucine rich transmembrane and 0-methyltransferase domain containing; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function | oral cancer overexpressed 1 | 0.617 |
| LRTOMT | PPFIA1 | ENSP00000305742 | ENSP00000253925 | leucine rich transmembrane and 0-methyltransferase domain containing; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates | 0.409 |
| LRTOMT | SHANK2 | ENSP00000305742 | ENSP00000345193 | leucine rich transmembrane and 0-methyltransferase domain containing; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function | SH3 and multiple ankyrin repeat domains 2; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction | 0.820 |
| LRTOMT | TMC1 | ENSP00000305742 | ENSP00000297784 | leucine rich transmembrane and 0-methyltransferase domain containing; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function | transmembrane channel-like 1; Probable ion channel required for the normal function of cochlear hair cells (By similarity) | 0.581 |
| ORAOV1 | CTTN | ENSP00000279147 | ENSP00000365745 | oral cancer overexpressed 1 | cortactin; Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases | 0.661 |
| ORAOV1 | LRTOMT | ENSP00000279147 | ENSP00000305742 | oral cancer overexpressed 1 | leucine rich transmembrane and 0-methyltransferase domain containing; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function | 0.617 |
| ORAOV1 | PPFIA1 | ENSP00000279147 | ENSP00000253925 | oral cancer overexpressed 1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates | 0.690 |
| ORAOV1 | SHANK2 | ENSP00000279147 | ENSP00000345193 | oral cancer overexpressed 1 | SH3 and multiple ankyrin repeat domains 2; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction | 0.428 |
| PPFIA1 | CTTN | ENSP00000253925 | ENSP00000365745 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates | cortactin; Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases | 0.494 |
| PPFIA1 | LRTOMT | ENSP00000253925 | ENSP00000305742 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates | leucine rich transmembrane and 0-methyltransferase domain containing; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function | 0.409 |
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