Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | STX18 | syntaxin 18; Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER (335 aa) | ||||||||||||
Predicted Functional Partners:
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 | RINT1 | RAD50 interactor 1; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum. May play a role in cell cycle checkpoint control. Essential for telomere length control (792 aa) |
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0.998 | |||||||||
 | SCFD1 | sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity) (642 aa) |
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0.997 | |||||||||
 | USE1 | unconventional SNARE in the ER 1 homolog (S. cerevisiae); SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER (259 aa) |
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0.996 | |||||||
 | RAB1A | RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity (205 aa) |
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0.974 | |||||||||
 | BNIP1 | BCL2/adenovirus E1B 19kDa interacting protein 1 (271 aa) |
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0.971 | ||||||||
 | STX5 | syntaxin 5; Mediates endoplasmic reticulum to Golgi transport (By similarity) (355 aa) |
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0.967 | |||||||||
 | SEC22C | SEC22 vesicle trafficking protein homolog C (S. cerevisiae); May be involved in vesicle transport between the ER and the Golgi complex (303 aa) |
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0.936 | |||||||||
 | SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae); May be involved in vesicle transport between the ER and the Golgi complex (By similarity) (307 aa) |
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0.925 | |||||||||
 | NAPA | N-ethylmaleimide-sensitive factor attachment protein, alpha; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (295 aa) |
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0.907 | |||||||||
 | ZW10 | ZW10, kinetochore associated, homolog (Drosophila); Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (779 aa) |
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0.899 | ||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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