splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes: protein of unknown 3D structure
large nodes: some 3D structure is known or predicted
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM208
transmembrane protein 208 (173 aa)
Predicted Functional Partners:
MCEE
methylmalonyl CoA epimerase (176 aa)
0.465
PIGO
phosphatidylinositol glycan anchor biosynthesis, class O; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond (By similarity) (1089 aa)
0.461
DNAJC15
DnaJ (Hsp40) homolog, subfamily C, member 15 (150 aa)
0.431
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606 Other names: H. sapiens, Homo, Homo sapiens, human, man
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
DNAJC15
TMEM208
ENSP00000368523
ENSP00000305892
DnaJ (Hsp40) homolog, subfamily C, member 15
transmembrane protein 208
0.431
MCEE
TMEM208
ENSP00000244217
ENSP00000305892
methylmalonyl CoA epimerase
transmembrane protein 208
0.465
PIGO
TMEM208
ENSP00000339382
ENSP00000305892
phosphatidylinositol glycan anchor biosynthesis, class O; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond (By similarity)
transmembrane protein 208
0.461
TMEM208
DNAJC15
ENSP00000305892
ENSP00000368523
transmembrane protein 208
DnaJ (Hsp40) homolog, subfamily C, member 15
0.431
TMEM208
MCEE
ENSP00000305892
ENSP00000244217
transmembrane protein 208
methylmalonyl CoA epimerase
0.465
TMEM208
PIGO
ENSP00000305892
ENSP00000339382
transmembrane protein 208
phosphatidylinositol glycan anchor biosynthesis, class O; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond (By similarity)
Groups of genes that are frequently observed in each other's genomic neighborhood.
Experiments
Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
Fusion
Genes that are sometimes fused into single open reading frames.
Databases
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Network Stats
Network Stats analysis is still ongoing, please wait ...
Functional enrichments in your networkNote: some enrichments may be expected here (why?)
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: