node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATF2 | TBP | ENSP00000264110 | ENSP00000230354 | activating transcription factor 2; Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus- 5’- GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex | TATA box binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 wi [...] | 0.434 |
ATF2 | UTF1 | ENSP00000264110 | ENSP00000305906 | activating transcription factor 2; Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus- 5’- GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex | undifferentiated embryonic cell transcription factor 1; Acts as a transcriptional coactivator of ATF2 | 0.917 |
FGF4 | GDF3 | ENSP00000168712 | ENSP00000331745 | fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis | growth differentiation factor 3 | 0.677 |
FGF4 | KLF4 | ENSP00000168712 | ENSP00000363804 | fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis | Kruppel-like factor 4 (gut); Transcription factor; can act both as activator and as repressor. Binds the 5’-CACCC-3’ core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may al [...] | 0.507 |
FGF4 | NANOG | ENSP00000168712 | ENSP00000229307 | fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis | Nanog homeobox; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5’-TAAT[GT][GT]-3’ or 5 [...] | 0.745 |
FGF4 | POU5F1 | ENSP00000168712 | ENSP00000259915 | fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis | POU class 5 homeobox 1 | 0.842 |
FGF4 | SOX2 | ENSP00000168712 | ENSP00000323588 | fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis | SRY (sex determining region Y)-box 2; Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiat [...] | 0.942 |
FGF4 | UTF1 | ENSP00000168712 | ENSP00000305906 | fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis | undifferentiated embryonic cell transcription factor 1; Acts as a transcriptional coactivator of ATF2 | 0.668 |
FGF4 | ZFP42 | ENSP00000168712 | ENSP00000317686 | fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis | zinc finger protein 42 homolog (mouse); Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity) | 0.480 |
GDF3 | FGF4 | ENSP00000331745 | ENSP00000168712 | growth differentiation factor 3 | fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis | 0.677 |
GDF3 | KLF4 | ENSP00000331745 | ENSP00000363804 | growth differentiation factor 3 | Kruppel-like factor 4 (gut); Transcription factor; can act both as activator and as repressor. Binds the 5’-CACCC-3’ core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may al [...] | 0.562 |
GDF3 | NANOG | ENSP00000331745 | ENSP00000229307 | growth differentiation factor 3 | Nanog homeobox; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5’-TAAT[GT][GT]-3’ or 5 [...] | 0.951 |
GDF3 | POU5F1 | ENSP00000331745 | ENSP00000259915 | growth differentiation factor 3 | POU class 5 homeobox 1 | 0.669 |
GDF3 | SALL4 | ENSP00000331745 | ENSP00000217086 | growth differentiation factor 3 | sal-like 4 (Drosophila); Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells | 0.472 |
GDF3 | SOX2 | ENSP00000331745 | ENSP00000323588 | growth differentiation factor 3 | SRY (sex determining region Y)-box 2; Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiat [...] | 0.635 |
GDF3 | UTF1 | ENSP00000331745 | ENSP00000305906 | growth differentiation factor 3 | undifferentiated embryonic cell transcription factor 1; Acts as a transcriptional coactivator of ATF2 | 0.611 |
GDF3 | ZFP42 | ENSP00000331745 | ENSP00000317686 | growth differentiation factor 3 | zinc finger protein 42 homolog (mouse); Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity) | 0.584 |
KLF4 | FGF4 | ENSP00000363804 | ENSP00000168712 | Kruppel-like factor 4 (gut); Transcription factor; can act both as activator and as repressor. Binds the 5’-CACCC-3’ core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may al [...] | fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis | 0.507 |
KLF4 | GDF3 | ENSP00000363804 | ENSP00000331745 | Kruppel-like factor 4 (gut); Transcription factor; can act both as activator and as repressor. Binds the 5’-CACCC-3’ core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may al [...] | growth differentiation factor 3 | 0.562 |
KLF4 | NANOG | ENSP00000363804 | ENSP00000229307 | Kruppel-like factor 4 (gut); Transcription factor; can act both as activator and as repressor. Binds the 5’-CACCC-3’ core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may al [...] | Nanog homeobox; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5’-TAAT[GT][GT]-3’ or 5 [...] | 0.999 |