| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDH23 | CLRN1 | ENSP00000381768 | ENSP00000329158 | cadherin-related 23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing | clarin 1; May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina | 0.701 |
| CDH23 | DFNB31 | ENSP00000381768 | ENSP00000354623 | cadherin-related 23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing | deafness, autosomal recessive 31 | 0.725 |
| CDH23 | PCDH15 | ENSP00000381768 | ENSP00000354950 | cadherin-related 23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing | protocadherin-related 15; Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function | 0.912 |
| CDH23 | PDZD7 | ENSP00000381768 | ENSP00000359234 | cadherin-related 23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing | PDZ domain containing 7 | 0.510 |
| CDH23 | USH1C | ENSP00000381768 | ENSP00000005226 | cadherin-related 23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing | Usher syndrome 1C (autosomal recessive, severe); Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing (By similarity) | 0.999 |
| CDH23 | USH2A | ENSP00000381768 | ENSP00000305941 | cadherin-related 23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing | Usher syndrome 2A (autosomal recessive, mild); Involved in hearing and vision | 0.730 |
| CLRN1 | CDH23 | ENSP00000329158 | ENSP00000381768 | clarin 1; May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina | cadherin-related 23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing | 0.701 |
| CLRN1 | DFNB31 | ENSP00000329158 | ENSP00000354623 | clarin 1; May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina | deafness, autosomal recessive 31 | 0.582 |
| CLRN1 | PCDH15 | ENSP00000329158 | ENSP00000354950 | clarin 1; May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina | protocadherin-related 15; Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function | 0.700 |
| CLRN1 | PDZD7 | ENSP00000329158 | ENSP00000359234 | clarin 1; May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina | PDZ domain containing 7 | 0.580 |
| CLRN1 | USH1C | ENSP00000329158 | ENSP00000005226 | clarin 1; May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina | Usher syndrome 1C (autosomal recessive, severe); Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing (By similarity) | 0.645 |
| CLRN1 | USH2A | ENSP00000329158 | ENSP00000305941 | clarin 1; May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina | Usher syndrome 2A (autosomal recessive, mild); Involved in hearing and vision | 0.811 |
| DFNB31 | CDH23 | ENSP00000354623 | ENSP00000381768 | deafness, autosomal recessive 31 | cadherin-related 23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing | 0.725 |
| DFNB31 | CLRN1 | ENSP00000354623 | ENSP00000329158 | deafness, autosomal recessive 31 | clarin 1; May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina | 0.582 |
| DFNB31 | LCA5 | ENSP00000354623 | ENSP00000358861 | deafness, autosomal recessive 31 | Leber congenital amaurosis 5; Might be involved in minus end-directed microtubule transport | 0.514 |
| DFNB31 | NINL | ENSP00000354623 | ENSP00000278886 | deafness, autosomal recessive 31 | ninein-like; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis | 0.608 |
| DFNB31 | PCDH15 | ENSP00000354623 | ENSP00000354950 | deafness, autosomal recessive 31 | protocadherin-related 15; Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function | 0.813 |
| DFNB31 | USH2A | ENSP00000354623 | ENSP00000305941 | deafness, autosomal recessive 31 | Usher syndrome 2A (autosomal recessive, mild); Involved in hearing and vision | 0.974 |
| HLA-G | USH2A | ENSP00000353472 | ENSP00000305941 | major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells | Usher syndrome 2A (autosomal recessive, mild); Involved in hearing and vision | 0.878 |
| KCTD3 | USH2A | ENSP00000259154 | ENSP00000305941 | potassium channel tetramerisation domain containing 3 | Usher syndrome 2A (autosomal recessive, mild); Involved in hearing and vision | 0.746 |
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