| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENO1 | ENO3 | ENSP00000234590 | ENSP00000324105 | enolase 1, (alpha) | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | 0.766 |
| ENO1 | GAPDH | ENSP00000234590 | ENSP00000229239 | enolase 1, (alpha) | glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | 0.999 |
| ENO1 | GAPDHS | ENSP00000234590 | ENSP00000222286 | enolase 1, (alpha) | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity) | 0.945 |
| ENO1 | PGAM1 | ENSP00000234590 | ENSP00000359991 | enolase 1, (alpha) | phosphoglycerate mutase 1 (brain); Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity | 0.867 |
| ENO1 | PGAM2 | ENSP00000234590 | ENSP00000297283 | enolase 1, (alpha) | phosphoglycerate mutase 2 (muscle); Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity | 0.835 |
| ENO1 | PGK2 | ENSP00000234590 | ENSP00000305995 | enolase 1, (alpha) | phosphoglycerate kinase 2 | 0.986 |
| ENO1 | PKLR | ENSP00000234590 | ENSP00000339933 | enolase 1, (alpha) | pyruvate kinase, liver and RBC; Plays a key role in glycolysis (By similarity) | 0.995 |
| ENO1 | PKM | ENSP00000234590 | ENSP00000320171 | enolase 1, (alpha) | pyruvate kinase, muscle | 0.996 |
| ENO1 | TPI1 | ENSP00000234590 | ENSP00000229270 | enolase 1, (alpha) | triosephosphate isomerase 1 | 0.991 |
| ENO2 | GAPDH | ENSP00000229277 | ENSP00000229239 | enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) | glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | 0.957 |
| ENO2 | GAPDHS | ENSP00000229277 | ENSP00000222286 | enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity) | 0.943 |
| ENO2 | PGAM1 | ENSP00000229277 | ENSP00000359991 | enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) | phosphoglycerate mutase 1 (brain); Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity | 0.757 |
| ENO2 | PGAM2 | ENSP00000229277 | ENSP00000297283 | enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) | phosphoglycerate mutase 2 (muscle); Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity | 0.725 |
| ENO2 | PGK2 | ENSP00000229277 | ENSP00000305995 | enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) | phosphoglycerate kinase 2 | 0.989 |
| ENO2 | PKLR | ENSP00000229277 | ENSP00000339933 | enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) | pyruvate kinase, liver and RBC; Plays a key role in glycolysis (By similarity) | 0.991 |
| ENO2 | PKM | ENSP00000229277 | ENSP00000320171 | enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) | pyruvate kinase, muscle | 0.993 |
| ENO2 | TPI1 | ENSP00000229277 | ENSP00000229270 | enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) | triosephosphate isomerase 1 | 0.990 |
| ENO3 | ENO1 | ENSP00000324105 | ENSP00000234590 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | enolase 1, (alpha) | 0.766 |
| ENO3 | GAPDH | ENSP00000324105 | ENSP00000229239 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | 0.958 |
| ENO3 | GAPDHS | ENSP00000324105 | ENSP00000222286 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity) | 0.942 |
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