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EGF EGF EGFR EGFR UBC UBC ASAP1 ASAP1 PLD2 PLD2 ARF4 ARF4 PKD1 PKD1 LRP2 LRP2 ARFGAP1 ARFGAP1 ARFGAP3 ARFGAP3 GGA3 GGA3
"ARF4" - ADP-ribosylation factor 4 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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white nodes:
second shell of interactors
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Predicted Interactions
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fusion edge
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Score
ARF4ADP-ribosylation factor 4; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (180 aa)    
Predicted Functional Partners:
EGFR
epidermal growth factor receptor (1210 aa)
        score_image score_image score_image   0.992
PLD2
phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity) (933 aa)
        score_image score_image score_image   0.966
PKD1
polycystic kidney disease 1 (autosomal dominant); Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By si [...] (4303 aa)
            score_image   0.943
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.929
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1; Possesses phosphatidylinositol 4,5-bisphosphate- dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis (1129 aa)
        score_image   score_image   0.927
EGF
epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (1207 aa)
          score_image     0.900
LRP2
low density lipoprotein receptor-related protein 2; Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release (4655 aa)
            score_image   0.891
ARFGAP1
ADP-ribosylation factor GTPase activating protein 1 (414 aa)
        score_image   score_image   0.862
GGA3
golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif (723 aa)
        score_image   score_image   0.811
ARFGAP3
ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (516 aa)
        score_image   score_image   0.809
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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