node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYB561 | PAM | ENSP00000354028 | ENSP00000306100 | cytochrome b-561; Secretory vesicle-specific electron transport protein | peptidylglycine alpha-amidating monooxygenase | 0.810 |
CYB561 | UBC | ENSP00000354028 | ENSP00000344818 | cytochrome b-561; Secretory vesicle-specific electron transport protein | ubiquitin C | 0.730 |
FXYD1 | PAM | ENSP00000343314 | ENSP00000306100 | FXYD domain containing ion transport regulator 1; May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed | peptidylglycine alpha-amidating monooxygenase | 0.686 |
KALRN | PAM | ENSP00000240874 | ENSP00000306100 | kalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity | peptidylglycine alpha-amidating monooxygenase | 0.807 |
MYC | PAM | ENSP00000367207 | ENSP00000306100 | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | peptidylglycine alpha-amidating monooxygenase | 0.633 |
MYC | UBC | ENSP00000367207 | ENSP00000344818 | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | ubiquitin C | 0.999 |
PAM | CYB561 | ENSP00000306100 | ENSP00000354028 | peptidylglycine alpha-amidating monooxygenase | cytochrome b-561; Secretory vesicle-specific electron transport protein | 0.810 |
PAM | FXYD1 | ENSP00000306100 | ENSP00000343314 | peptidylglycine alpha-amidating monooxygenase | FXYD domain containing ion transport regulator 1; May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed | 0.686 |
PAM | KALRN | ENSP00000306100 | ENSP00000240874 | peptidylglycine alpha-amidating monooxygenase | kalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity | 0.807 |
PAM | MYC | ENSP00000306100 | ENSP00000367207 | peptidylglycine alpha-amidating monooxygenase | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | 0.633 |
PAM | POMC | ENSP00000306100 | ENSP00000264708 | peptidylglycine alpha-amidating monooxygenase | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.768 |
PAM | PRKCA | ENSP00000306100 | ENSP00000408695 | peptidylglycine alpha-amidating monooxygenase | protein kinase C, alpha; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycl [...] | 0.589 |
PAM | RASSF9 | ENSP00000306100 | ENSP00000354884 | peptidylglycine alpha-amidating monooxygenase | Ras association (RalGDS/AF-6) domain family (N-terminal) member 9; May play a role in regulating vesicuar trafficking in cells (By similarity) | 0.846 |
PAM | TOR2A | ENSP00000306100 | ENSP00000362381 | peptidylglycine alpha-amidating monooxygenase | torsin family 2, member A; Salusins -alpha and -beta may be endocrine and/or paracrine factors able to increase intracellular calcium concentrations and induce cell mitogenesis. Salusins may also be potent hypotensive peptides | 0.812 |
PAM | UBC | ENSP00000306100 | ENSP00000344818 | peptidylglycine alpha-amidating monooxygenase | ubiquitin C | 0.641 |
PAM | UHMK1 | ENSP00000306100 | ENSP00000420270 | peptidylglycine alpha-amidating monooxygenase | U2AF homology motif (UHM) kinase 1; Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity) | 0.675 |
POMC | PAM | ENSP00000264708 | ENSP00000306100 | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | peptidylglycine alpha-amidating monooxygenase | 0.768 |
PRKCA | PAM | ENSP00000408695 | ENSP00000306100 | protein kinase C, alpha; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycl [...] | peptidylglycine alpha-amidating monooxygenase | 0.589 |
PRKCA | UBC | ENSP00000408695 | ENSP00000344818 | protein kinase C, alpha; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycl [...] | ubiquitin C | 0.981 |
RASSF9 | PAM | ENSP00000354884 | ENSP00000306100 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 9; May play a role in regulating vesicuar trafficking in cells (By similarity) | peptidylglycine alpha-amidating monooxygenase | 0.846 |