node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANTXR1 | ANTXR2 | ENSP00000301945 | ENSP00000306185 | anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | 0.903 |
ANTXR1 | DPH1 | ENSP00000301945 | ENSP00000263083 | anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells | DPH1 homolog (S. cerevisiae); Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity) | 0.480 |
ANTXR1 | LRP6 | ENSP00000301945 | ENSP00000261349 | anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells | low density lipoprotein receptor-related protein 6; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction o [...] | 0.766 |
ANTXR1 | UBC | ENSP00000301945 | ENSP00000344818 | anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells | ubiquitin C | 0.893 |
ANTXR2 | ANTXR1 | ENSP00000306185 | ENSP00000301945 | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells | 0.903 |
ANTXR2 | ASAH1 | ENSP00000306185 | ENSP00000371152 | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | N-acylsphingosine amidohydrolase (acid ceramidase) 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | 0.655 |
ANTXR2 | BICD1 | ENSP00000306185 | ENSP00000281474 | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | bicaudal D homolog 1 (Drosophila); Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex | 0.744 |
ANTXR2 | COL4A2 | ENSP00000306185 | ENSP00000353654 | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | collagen, type IV, alpha 2; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.569 |
ANTXR2 | COL4A3 | ENSP00000306185 | ENSP00000379823 | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | collagen, type IV, alpha 3 (Goodpasture antigen) | 0.567 |
ANTXR2 | COL4A4 | ENSP00000306185 | ENSP00000379866 | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | collagen, type IV, alpha 4; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.567 |
ANTXR2 | DPH1 | ENSP00000306185 | ENSP00000263083 | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | DPH1 homolog (S. cerevisiae); Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity) | 0.609 |
ANTXR2 | LRP6 | ENSP00000306185 | ENSP00000261349 | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | low density lipoprotein receptor-related protein 6; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction o [...] | 0.717 |
ANTXR2 | MMP14 | ENSP00000306185 | ENSP00000308208 | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | matrix metallopeptidase 14 (membrane-inserted); Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 | 0.812 |
ANTXR2 | UBC | ENSP00000306185 | ENSP00000344818 | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | ubiquitin C | 0.911 |
ASAH1 | ANTXR2 | ENSP00000371152 | ENSP00000306185 | N-acylsphingosine amidohydrolase (acid ceramidase) 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | 0.655 |
ASAH1 | UBC | ENSP00000371152 | ENSP00000344818 | N-acylsphingosine amidohydrolase (acid ceramidase) 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | ubiquitin C | 0.484 |
BICD1 | ANTXR2 | ENSP00000281474 | ENSP00000306185 | bicaudal D homolog 1 (Drosophila); Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | 0.744 |
COL4A2 | ANTXR2 | ENSP00000353654 | ENSP00000306185 | collagen, type IV, alpha 2; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | 0.569 |
COL4A2 | COL4A3 | ENSP00000353654 | ENSP00000379823 | collagen, type IV, alpha 2; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | collagen, type IV, alpha 3 (Goodpasture antigen) | 0.919 |
COL4A2 | COL4A4 | ENSP00000353654 | ENSP00000379866 | collagen, type IV, alpha 2; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | collagen, type IV, alpha 4; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.923 |