KRT78 protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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Score

KRT78

keratin 78 (520 aa)

Predicted Functional Partners:

UBC

0.741

KRT16

0.661

CDC42BPB

0.504

C15orf40

0.499

SYCP2L

0.475

ENSG00000212857

0.472

KIAA1984

0.459

LCE1E

0.457

EIF2A

0.420

TMEM63C

0.418

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C15orf40	KRT78	ENSP00000403987	ENSP00000306261	chromosome 15 open reading frame 40	keratin 78	0.499
C15orf40	LCE1E	ENSP00000403987	ENSP00000357759	chromosome 15 open reading frame 40	late cornified envelope 1E; Precursors of the cornified envelope of the stratum corneum	0.584
C15orf40	UBC	ENSP00000403987	ENSP00000344818	chromosome 15 open reading frame 40	ubiquitin C	0.620
CDC42BPB	KRT78	ENSP00000355237	ENSP00000306261	CDC42 binding protein kinase beta (DMPK-like); Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A	keratin 78	0.504
CDC42BPB	UBC	ENSP00000355237	ENSP00000344818	CDC42 binding protein kinase beta (DMPK-like); Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A	ubiquitin C	0.751
EIF2A	ENSG00000212857	ENSP00000417229	ENSP00000375387	eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins	Uncharacterized protein DKFZp434B061	0.568
EIF2A	KRT78	ENSP00000417229	ENSP00000306261	eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins	keratin 78	0.420
EIF2A	UBC	ENSP00000417229	ENSP00000344818	eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins	ubiquitin C	0.920
ENSG00000212857	EIF2A	ENSP00000375387	ENSP00000417229	Uncharacterized protein DKFZp434B061	eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins	0.568
ENSG00000212857	KRT78	ENSP00000375387	ENSP00000306261	Uncharacterized protein DKFZp434B061	keratin 78	0.472
KIAA1984	KRT78	ENSP00000338013	ENSP00000306261	KIAA1984	keratin 78	0.459
KRT16	KRT78	ENSP00000301653	ENSP00000306261	keratin 16	keratin 78	0.661
KRT16	UBC	ENSP00000301653	ENSP00000344818	keratin 16	ubiquitin C	0.837
KRT78	C15orf40	ENSP00000306261	ENSP00000403987	keratin 78	chromosome 15 open reading frame 40	0.499
KRT78	CDC42BPB	ENSP00000306261	ENSP00000355237	keratin 78	CDC42 binding protein kinase beta (DMPK-like); Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A	0.504
KRT78	EIF2A	ENSP00000306261	ENSP00000417229	keratin 78	eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins	0.420
KRT78	ENSG00000212857	ENSP00000306261	ENSP00000375387	keratin 78	Uncharacterized protein DKFZp434B061	0.472
KRT78	KIAA1984	ENSP00000306261	ENSP00000338013	keratin 78	KIAA1984	0.459
KRT78	KRT16	ENSP00000306261	ENSP00000301653	keratin 78	keratin 16	0.661
KRT78	LCE1E	ENSP00000306261	ENSP00000357759	keratin 78	late cornified envelope 1E; Precursors of the cornified envelope of the stratum corneum	0.457

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