| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATR | CHEK2 | ENSP00000343741 | ENSP00000372023 | ataxia telangiectasia and Rad3 related; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damag [...] | checkpoint kinase 2 | 0.999 |
| ATR | DCLK2 | ENSP00000343741 | ENSP00000303887 | ataxia telangiectasia and Rad3 related; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damag [...] | doublecortin-like kinase 2; Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity) | 0.882 |
| ATR | DCLK3 | ENSP00000343741 | ENSP00000394484 | ataxia telangiectasia and Rad3 related; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damag [...] | doublecortin-like kinase 3 | 0.882 |
| ATR | RFX2 | ENSP00000343741 | ENSP00000306335 | ataxia telangiectasia and Rad3 related; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damag [...] | regulatory factor X, 2 (influences HLA class II expression) | 0.780 |
| CHEK2 | ATR | ENSP00000372023 | ENSP00000343741 | checkpoint kinase 2 | ataxia telangiectasia and Rad3 related; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damag [...] | 0.999 |
| CHEK2 | RFX2 | ENSP00000372023 | ENSP00000306335 | checkpoint kinase 2 | regulatory factor X, 2 (influences HLA class II expression) | 0.740 |
| DCLK2 | ATR | ENSP00000303887 | ENSP00000343741 | doublecortin-like kinase 2; Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity) | ataxia telangiectasia and Rad3 related; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damag [...] | 0.882 |
| DCLK2 | RFX2 | ENSP00000303887 | ENSP00000306335 | doublecortin-like kinase 2; Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity) | regulatory factor X, 2 (influences HLA class II expression) | 0.740 |
| DCLK3 | ATR | ENSP00000394484 | ENSP00000343741 | doublecortin-like kinase 3 | ataxia telangiectasia and Rad3 related; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damag [...] | 0.882 |
| DCLK3 | RFX2 | ENSP00000394484 | ENSP00000306335 | doublecortin-like kinase 3 | regulatory factor X, 2 (influences HLA class II expression) | 0.740 |
| FOXJ1 | RFX2 | ENSP00000323880 | ENSP00000306335 | forkhead box J1; May play an important role in cell fate determination during lung development and in spermatogenesis (By similarity) | regulatory factor X, 2 (influences HLA class II expression) | 0.815 |
| HIST1H1T | RFX2 | ENSP00000341214 | ENSP00000306335 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | regulatory factor X, 2 (influences HLA class II expression) | 0.897 |
| KDM6A | RFX2 | ENSP00000367203 | ENSP00000306335 | lysine (K)-specific demethylase 6A; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of ’Lys-27’ of histone H3 is concomitant with methylation of ’Lys-4’ of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A | regulatory factor X, 2 (influences HLA class II expression) | 0.714 |
| MYBL1 | RFX2 | ENSP00000429633 | ENSP00000306335 | v-myb myeloblastosis viral oncogene homolog (avian)-like 1; Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence 5’-YAAC[GT]G-3’. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells | regulatory factor X, 2 (influences HLA class II expression) | 0.897 |
| RFX2 | ATR | ENSP00000306335 | ENSP00000343741 | regulatory factor X, 2 (influences HLA class II expression) | ataxia telangiectasia and Rad3 related; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damag [...] | 0.780 |
| RFX2 | CHEK2 | ENSP00000306335 | ENSP00000372023 | regulatory factor X, 2 (influences HLA class II expression) | checkpoint kinase 2 | 0.740 |
| RFX2 | DCLK2 | ENSP00000306335 | ENSP00000303887 | regulatory factor X, 2 (influences HLA class II expression) | doublecortin-like kinase 2; Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity) | 0.740 |
| RFX2 | DCLK3 | ENSP00000306335 | ENSP00000394484 | regulatory factor X, 2 (influences HLA class II expression) | doublecortin-like kinase 3 | 0.740 |
| RFX2 | FOXJ1 | ENSP00000306335 | ENSP00000323880 | regulatory factor X, 2 (influences HLA class II expression) | forkhead box J1; May play an important role in cell fate determination during lung development and in spermatogenesis (By similarity) | 0.815 |
| RFX2 | HIST1H1T | ENSP00000306335 | ENSP00000341214 | regulatory factor X, 2 (influences HLA class II expression) | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | 0.897 |
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