Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
|
Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
|||||
 | CHCHD7 | coiled-coil-helix-coiled-coil-helix domain containing 7 (110 aa) | ||||||||||||
Predicted Functional Partners:
| ||||||||||||||
 | COX19 | cytochrome c oxidase assembly homolog 19 (S. cerevisiae); May be required for the assembly of mitochondrial cytochrome c oxidase (By similarity) (90 aa) |
 |
0.873 | ||||||||||
 | PLAG1 | pleiomorphic adenoma gene 1; Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation- when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hep [...] (500 aa) |
|
0.782 | ||||||||||
 | COA5 | cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process (74 aa) |
|
0.752 | ||||||||||
 | CHURC1 | churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself (140 aa) |
|
0.746 | ||||||||||
 | COX11 | cytochrome c oxidase assembly homolog 11 (yeast); Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) (276 aa) |
|
|
0.716 | |||||||||
 | COX17 | cytochrome c oxidase assembly homolog 17 (yeast); Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX (By similarity) (63 aa) |
|
0.715 | ||||||||||
 | CHCHD5 | coiled-coil-helix-coiled-coil-helix domain containing 5 (110 aa) |
|
0.706 | ||||||||||
 | SDR16C5 | short chain dehydrogenase/reductase family 16C, member 5; Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH (309 aa) |
|
0.697 | ||||||||||
 | CMC1 | COX assembly mitochondrial protein 1 homolog (S. cerevisiae); Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration (By similarity) (106 aa) |
|
|
0.696 | |||||||||
 | PPP2R2D | protein phosphatase 2, regulatory subunit B, delta; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55- delta) fluctuate during the cell cycle- the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of t [...] (422 aa) |
|
0.695 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
Share
