BTD protein (Homo sapiens) - STRING network view

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BTD

biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation (543 aa)

Predicted Functional Partners:

HLCS

0.987

AASS

0.823

PC

0.809

MCCC1

0.772

MCCC2

0.763

USHBP1

0.758

PCCA

0.696

ACACA

0.645

SLC5A6

0.602

SLC19A3

0.589

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AASS	BTD	ENSP00000377040	ENSP00000306477	aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively	biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation	0.823
ACACA	BTD	ENSP00000344789	ENSP00000306477	acetyl-CoA carboxylase alpha	biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation	0.645
ACACA	HLCS	ENSP00000344789	ENSP00000338387	acetyl-CoA carboxylase alpha	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase	0.995
ACACA	MCCC1	ENSP00000344789	ENSP00000265594	acetyl-CoA carboxylase alpha	methylcrotonoyl-CoA carboxylase 1 (alpha)	0.841
ACACA	MCCC2	ENSP00000344789	ENSP00000343657	acetyl-CoA carboxylase alpha	methylcrotonoyl-CoA carboxylase 2 (beta)	0.860
ACACA	PC	ENSP00000344789	ENSP00000377527	acetyl-CoA carboxylase alpha	pyruvate carboxylase; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate	0.638
ACACA	PCCA	ENSP00000344789	ENSP00000365462	acetyl-CoA carboxylase alpha	propionyl CoA carboxylase, alpha polypeptide	0.839
ACACA	SLC5A6	ENSP00000344789	ENSP00000310208	acetyl-CoA carboxylase alpha	solute carrier family 5 (sodium-dependent vitamin transporter), member 6; Transports pantothenate, biotin and lipoate in the presence of sodium	0.951
BTD	AASS	ENSP00000306477	ENSP00000377040	biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation	aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively	0.823
BTD	ACACA	ENSP00000306477	ENSP00000344789	biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation	acetyl-CoA carboxylase alpha	0.645
BTD	HLCS	ENSP00000306477	ENSP00000338387	biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase	0.987
BTD	MCCC1	ENSP00000306477	ENSP00000265594	biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation	methylcrotonoyl-CoA carboxylase 1 (alpha)	0.772
BTD	MCCC2	ENSP00000306477	ENSP00000343657	biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation	methylcrotonoyl-CoA carboxylase 2 (beta)	0.763
BTD	PC	ENSP00000306477	ENSP00000377527	biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation	pyruvate carboxylase; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate	0.809
BTD	PCCA	ENSP00000306477	ENSP00000365462	biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation	propionyl CoA carboxylase, alpha polypeptide	0.696
BTD	SLC19A3	ENSP00000306477	ENSP00000258403	biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation	solute carrier family 19, member 3; Mediates high affinity thiamine uptake, propably via a proton anti-port mechanism. Has no folate transport activity	0.589
BTD	SLC5A6	ENSP00000306477	ENSP00000310208	biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation	solute carrier family 5 (sodium-dependent vitamin transporter), member 6; Transports pantothenate, biotin and lipoate in the presence of sodium	0.602
BTD	USHBP1	ENSP00000306477	ENSP00000252597	biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation	Usher syndrome 1C binding protein 1	0.758
HLCS	ACACA	ENSP00000338387	ENSP00000344789	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase	acetyl-CoA carboxylase alpha	0.995
HLCS	BTD	ENSP00000338387	ENSP00000306477	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase	biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation	0.987

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