node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAMTA1 | CNOT6L | ENSP00000306522 | ENSP00000264903 | calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor | CCR4-NOT transcription complex, subunit 6-like; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3 [...] | 0.558 |
CAMTA1 | DYNC1I1 | ENSP00000306522 | ENSP00000320130 | calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor | dynein, cytoplasmic 1, intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and k [...] | 0.551 |
CAMTA1 | DYNC1I2 | ENSP00000306522 | ENSP00000380308 | calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor | dynein, cytoplasmic 1, intermediate chain 2 | 0.564 |
CAMTA1 | IMPAD1 | ENSP00000306522 | ENSP00000262644 | calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor | inositol monophosphatase domain containing 1; May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3’,5’-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation (By similarity) | 0.580 |
CAMTA1 | KLHL21 | ENSP00000306522 | ENSP00000366886 | calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor | kelch-like 21 (Drosophila); Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome | 0.569 |
CAMTA1 | NPHP4 | ENSP00000306522 | ENSP00000367398 | calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor | nephronophthisis 4; Involved in the organization of apical junctions in kidney cells together with NPHP1 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity) | 0.528 |
CAMTA1 | NPPA | ENSP00000306522 | ENSP00000365663 | calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor | natriuretic peptide A; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 | 0.754 |
CAMTA1 | PRKD1 | ENSP00000306522 | ENSP00000333568 | calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor | protein kinase D1; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphoryl [...] | 0.519 |
CAMTA1 | RCAN3 | ENSP00000306522 | ENSP00000363516 | calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor | RCAN family member 3; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity) | 0.526 |
CAMTA1 | WWTR1 | ENSP00000306522 | ENSP00000353847 | calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor | WW domain containing transcription regulator 1; Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 an [...] | 0.620 |
CNOT6L | CAMTA1 | ENSP00000264903 | ENSP00000306522 | CCR4-NOT transcription complex, subunit 6-like; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3 [...] | calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor | 0.558 |
CNOT6L | IMPAD1 | ENSP00000264903 | ENSP00000262644 | CCR4-NOT transcription complex, subunit 6-like; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3 [...] | inositol monophosphatase domain containing 1; May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3’,5’-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation (By similarity) | 0.580 |
DYNC1I1 | CAMTA1 | ENSP00000320130 | ENSP00000306522 | dynein, cytoplasmic 1, intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and k [...] | calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor | 0.551 |
DYNC1I1 | DYNC1I2 | ENSP00000320130 | ENSP00000380308 | dynein, cytoplasmic 1, intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and k [...] | dynein, cytoplasmic 1, intermediate chain 2 | 0.901 |
DYNC1I2 | CAMTA1 | ENSP00000380308 | ENSP00000306522 | dynein, cytoplasmic 1, intermediate chain 2 | calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor | 0.564 |
DYNC1I2 | DYNC1I1 | ENSP00000380308 | ENSP00000320130 | dynein, cytoplasmic 1, intermediate chain 2 | dynein, cytoplasmic 1, intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and k [...] | 0.901 |
IMPAD1 | CAMTA1 | ENSP00000262644 | ENSP00000306522 | inositol monophosphatase domain containing 1; May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3’,5’-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation (By similarity) | calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor | 0.580 |
IMPAD1 | CNOT6L | ENSP00000262644 | ENSP00000264903 | inositol monophosphatase domain containing 1; May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3’,5’-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation (By similarity) | CCR4-NOT transcription complex, subunit 6-like; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3 [...] | 0.580 |
KLHL21 | CAMTA1 | ENSP00000366886 | ENSP00000306522 | kelch-like 21 (Drosophila); Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome | calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor | 0.569 |
KLHL21 | NPHP4 | ENSP00000366886 | ENSP00000367398 | kelch-like 21 (Drosophila); Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome | nephronophthisis 4; Involved in the organization of apical junctions in kidney cells together with NPHP1 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity) | 0.611 |