node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAL | INSM2 | ENSP00000413074 | ENSP00000306523 | adenosine deaminase-like; Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity) | insulinoma-associated 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity) | 0.417 |
IKZF5 | INSM2 | ENSP00000357881 | ENSP00000306523 | IKAROS family zinc finger 5 (Pegasus); DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor | insulinoma-associated 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity) | 0.473 |
INSM2 | ADAL | ENSP00000306523 | ENSP00000413074 | insulinoma-associated 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity) | adenosine deaminase-like; Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity) | 0.417 |
INSM2 | IKZF5 | ENSP00000306523 | ENSP00000357881 | insulinoma-associated 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity) | IKAROS family zinc finger 5 (Pegasus); DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor | 0.473 |
INSM2 | MAPK8IP1 | ENSP00000306523 | ENSP00000241014 | insulinoma-associated 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity) | mitogen-activated protein kinase 8 interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fun [...] | 0.506 |
INSM2 | OPA3 | ENSP00000306523 | ENSP00000319817 | insulinoma-associated 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity) | optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia); May play some role in mitochondrial processes | 0.482 |
INSM2 | PIGT | ENSP00000306523 | ENSP00000279036 | insulinoma-associated 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity) | phosphatidylinositol glycan anchor biosynthesis, class T | 0.485 |
INSM2 | PTPRN | ENSP00000306523 | ENSP00000295718 | insulinoma-associated 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity) | protein tyrosine phosphatase, receptor type, N; Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 | 0.508 |
INSM2 | TEAD1 | ENSP00000306523 | ENSP00000354588 | insulinoma-associated 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity) | TEA domain family member 1 (SV40 transcriptional enhancer factor); Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/ [...] | 0.761 |
INSM2 | TEAD2 | ENSP00000306523 | ENSP00000310701 | insulinoma-associated 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity) | TEA domain family member 2; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferat [...] | 0.761 |
INSM2 | TEAD3 | ENSP00000306523 | ENSP00000345772 | insulinoma-associated 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity) | TEA domain family member 3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferat [...] | 0.761 |
INSM2 | TEAD4 | ENSP00000306523 | ENSP00000352926 | insulinoma-associated 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity) | TEA domain family member 4; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferat [...] | 0.761 |
MAPK8IP1 | INSM2 | ENSP00000241014 | ENSP00000306523 | mitogen-activated protein kinase 8 interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fun [...] | insulinoma-associated 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity) | 0.506 |
MAPK8IP1 | PTPRN | ENSP00000241014 | ENSP00000295718 | mitogen-activated protein kinase 8 interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fun [...] | protein tyrosine phosphatase, receptor type, N; Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 | 0.816 |
OPA3 | INSM2 | ENSP00000319817 | ENSP00000306523 | optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia); May play some role in mitochondrial processes | insulinoma-associated 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity) | 0.482 |
PIGT | INSM2 | ENSP00000279036 | ENSP00000306523 | phosphatidylinositol glycan anchor biosynthesis, class T | insulinoma-associated 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity) | 0.485 |
PTPRN | INSM2 | ENSP00000295718 | ENSP00000306523 | protein tyrosine phosphatase, receptor type, N; Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 | insulinoma-associated 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity) | 0.508 |
PTPRN | MAPK8IP1 | ENSP00000295718 | ENSP00000241014 | protein tyrosine phosphatase, receptor type, N; Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 | mitogen-activated protein kinase 8 interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fun [...] | 0.816 |
TEAD1 | INSM2 | ENSP00000354588 | ENSP00000306523 | TEA domain family member 1 (SV40 transcriptional enhancer factor); Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/ [...] | insulinoma-associated 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity) | 0.761 |
TEAD1 | TEAD2 | ENSP00000354588 | ENSP00000310701 | TEA domain family member 1 (SV40 transcriptional enhancer factor); Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/ [...] | TEA domain family member 2; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferat [...] | 0.902 |