node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADH1B | ALDH1A1 | ENSP00000306606 | ENSP00000297785 | alcohol dehydrogenase 1B (class I), beta polypeptide | aldehyde dehydrogenase 1 family, member A1; Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity) | 0.970 |
ADH1B | ALDH1A3 | ENSP00000306606 | ENSP00000332256 | alcohol dehydrogenase 1B (class I), beta polypeptide | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | 0.958 |
ADH1B | ALDH1B1 | ENSP00000306606 | ENSP00000366927 | alcohol dehydrogenase 1B (class I), beta polypeptide | aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation | 0.971 |
ADH1B | ALDH3A1 | ENSP00000306606 | ENSP00000225740 | alcohol dehydrogenase 1B (class I), beta polypeptide | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes | 0.960 |
ADH1B | ALDH3A2 | ENSP00000306606 | ENSP00000345774 | alcohol dehydrogenase 1B (class I), beta polypeptide | aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid | 0.961 |
ADH1B | ALDH3B2 | ENSP00000306606 | ENSP00000255084 | alcohol dehydrogenase 1B (class I), beta polypeptide | aldehyde dehydrogenase 3 family, member B2 | 0.960 |
ADH1B | AOX1 | ENSP00000306606 | ENSP00000363832 | alcohol dehydrogenase 1B (class I), beta polypeptide | aldehyde oxidase 1 | 0.952 |
ADH1B | CYP2E1 | ENSP00000306606 | ENSP00000252945 | alcohol dehydrogenase 1B (class I), beta polypeptide | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | 0.972 |
ADH1B | GSTM1 | ENSP00000306606 | ENSP00000311469 | alcohol dehydrogenase 1B (class I), beta polypeptide | glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles | 0.954 |
ADH1B | GSTT1 | ENSP00000306606 | ENSP00000248935 | alcohol dehydrogenase 1B (class I), beta polypeptide | glutathione S-transferase theta 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide | 0.950 |
ALDH1A1 | ADH1B | ENSP00000297785 | ENSP00000306606 | aldehyde dehydrogenase 1 family, member A1; Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity) | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.970 |
ALDH1A1 | CYP2E1 | ENSP00000297785 | ENSP00000252945 | aldehyde dehydrogenase 1 family, member A1; Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity) | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | 0.506 |
ALDH1A3 | ADH1B | ENSP00000332256 | ENSP00000306606 | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.958 |
ALDH1A3 | CYP2E1 | ENSP00000332256 | ENSP00000252945 | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | 0.915 |
ALDH1A3 | GSTM1 | ENSP00000332256 | ENSP00000311469 | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles | 0.902 |
ALDH1A3 | GSTT1 | ENSP00000332256 | ENSP00000248935 | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | glutathione S-transferase theta 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide | 0.911 |
ALDH1B1 | ADH1B | ENSP00000366927 | ENSP00000306606 | aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.971 |
ALDH3A1 | ADH1B | ENSP00000225740 | ENSP00000306606 | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.960 |
ALDH3A1 | CYP2E1 | ENSP00000225740 | ENSP00000252945 | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | 0.913 |
ALDH3A1 | GSTM1 | ENSP00000225740 | ENSP00000311469 | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes | glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles | 0.921 |