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NAB1 NAB1 ADCY10 ADCY10 SLC9A2 SLC9A2 TMCO3 TMCO3 NAB2 NAB2 SLC9C1 SLC9C1 TBC1D5 TBC1D5 SLC9A1 SLC9A1 SLC9A5 SLC9A5 SYT1 SYT1 SLC5A5 SLC5A5
"SLC9C1" - solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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Predicted Interactions
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SLC9C1solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1; Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity) (1177 aa)    
Predicted Functional Partners:
ADCY10
adenylate cyclase 10 (soluble); Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation (1610 aa)
       score_image score_image   score_image   0.917
SLC9A1
solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (815 aa)
             score_image   0.900
TBC1D5
TBC1 domain family, member 5; May act as a GTPase-activating protein for Rab family protein(s) (817 aa)
         score_image   score_image   0.766
TMCO3
transmembrane and coiled-coil domains 3; Probable Na(+)/H(+) antiporter (By similarity) (677 aa)
         score_image   score_image   0.748
SLC9A5
solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity) (896 aa)
             score_image   0.566
SYT1
synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 (422 aa)
             score_image   0.562
SLC9A2
solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption (812 aa)
             score_image   0.536
NAB1
NGFI-A binding protein 1 (EGR1 binding protein 1); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 (By similarity) (487 aa)
             score_image   0.518
NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity) (525 aa)
             score_image   0.518
SLC5A5
solute carrier family 5 (sodium iodide symporter), member 5; Mediates iodide uptake in the thyroid gland (643 aa)
             score_image   0.515
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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