| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BOLA2B | BOLA3 | ENSP00000306752 | ENSP00000331369 | bolA homolog 2B (E. coli) | bolA homolog 3 (E. coli) | 0.929 |
| BOLA2B | FKBP1A | ENSP00000306752 | ENSP00000371138 | bolA homolog 2B (E. coli) | FK506 binding protein 1A, 12kDa; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | 0.817 |
| BOLA2B | FKBP1B | ENSP00000306752 | ENSP00000370373 | bolA homolog 2B (E. coli) | FK506 binding protein 1B, 12.6 kDa; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | 0.817 |
| BOLA2B | FKBP1C | ENSP00000306752 | ENSP00000359693 | bolA homolog 2B (E. coli) | FK506 binding protein 1C | 0.817 |
| BOLA2B | GLRX3 | ENSP00000306752 | ENSP00000330836 | bolA homolog 2B (E. coli) | glutaredoxin 3; Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity | 0.871 |
| BOLA2B | GLRX5 | ENSP00000306752 | ENSP00000328570 | bolA homolog 2B (E. coli) | glutaredoxin 5; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 | 0.828 |
| BOLA2B | MAPKAP1 | ENSP00000306752 | ENSP00000265960 | bolA homolog 2B (E. coli) | mitogen-activated protein kinase associated protein 1 | 0.890 |
| BOLA2B | MLST8 | ENSP00000306752 | ENSP00000380313 | bolA homolog 2B (E. coli) | MTOR associated protein, LST8 homolog (S. cerevisiae) | 0.897 |
| BOLA2B | RICTOR | ENSP00000306752 | ENSP00000349959 | bolA homolog 2B (E. coli) | RPTOR independent companion of MTOR, complex 2; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 ’Ser-473’ phosphorylation, which may facilitate the phosphorylation of th [...] | 0.959 |
| BOLA2B | RPTOR | ENSP00000306752 | ENSP00000307272 | bolA homolog 2B (E. coli) | regulatory associated protein of MTOR, complex 1; Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signa [...] | 0.945 |
| BOLA3 | BOLA2B | ENSP00000331369 | ENSP00000306752 | bolA homolog 3 (E. coli) | bolA homolog 2B (E. coli) | 0.929 |
| BOLA3 | GLRX3 | ENSP00000331369 | ENSP00000330836 | bolA homolog 3 (E. coli) | glutaredoxin 3; Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity | 0.828 |
| BOLA3 | GLRX5 | ENSP00000331369 | ENSP00000328570 | bolA homolog 3 (E. coli) | glutaredoxin 5; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 | 0.881 |
| FKBP1A | BOLA2B | ENSP00000371138 | ENSP00000306752 | FK506 binding protein 1A, 12kDa; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | bolA homolog 2B (E. coli) | 0.817 |
| FKBP1A | MAPKAP1 | ENSP00000371138 | ENSP00000265960 | FK506 binding protein 1A, 12kDa; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | mitogen-activated protein kinase associated protein 1 | 0.471 |
| FKBP1A | MLST8 | ENSP00000371138 | ENSP00000380313 | FK506 binding protein 1A, 12kDa; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | MTOR associated protein, LST8 homolog (S. cerevisiae) | 0.825 |
| FKBP1A | RICTOR | ENSP00000371138 | ENSP00000349959 | FK506 binding protein 1A, 12kDa; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | RPTOR independent companion of MTOR, complex 2; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 ’Ser-473’ phosphorylation, which may facilitate the phosphorylation of th [...] | 0.774 |
| FKBP1A | RPTOR | ENSP00000371138 | ENSP00000307272 | FK506 binding protein 1A, 12kDa; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | regulatory associated protein of MTOR, complex 1; Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signa [...] | 0.978 |
| FKBP1B | BOLA2B | ENSP00000370373 | ENSP00000306752 | FK506 binding protein 1B, 12.6 kDa; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | bolA homolog 2B (E. coli) | 0.817 |
| FKBP1B | MLST8 | ENSP00000370373 | ENSP00000380313 | FK506 binding protein 1B, 12.6 kDa; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | MTOR associated protein, LST8 homolog (S. cerevisiae) | 0.543 |
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