| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APAF1 | AVEN | ENSP00000448165 | ENSP00000306822 | apoptotic peptidase activating factor 1 | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | 0.786 |
| APAF1 | BCL2L1 | ENSP00000448165 | ENSP00000302564 | apoptotic peptidase activating factor 1 | BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis | 0.999 |
| ATP5A1 | AVEN | ENSP00000282050 | ENSP00000306822 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of [...] | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | 0.813 |
| ATP5A1 | GPR83 | ENSP00000282050 | ENSP00000243673 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of [...] | G protein-coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor | 0.824 |
| ATP5A1 | HELT | ENSP00000282050 | ENSP00000343464 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of [...] | helt bHLH transcription factor; Transcriptional repressor which binds preferentially to the canonical E box sequence 5’-CACGCG-3’ (By similarity) | 0.813 |
| ATP5A1 | MEST | ENSP00000282050 | ENSP00000223215 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of [...] | mesoderm specific transcript homolog (mouse) | 0.834 |
| ATP5A1 | OVGP1 | ENSP00000282050 | ENSP00000358747 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of [...] | oviductal glycoprotein 1, 120kDa; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development | 0.757 |
| ATP5A1 | SELV | ENSP00000282050 | ENSP00000333956 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of [...] | selenoprotein V ; May be involved in a redox-related process (Potential) | 0.871 |
| ATP5A1 | SLC22A4 | ENSP00000282050 | ENSP00000200652 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of [...] | solute carrier family 22 (organic cation/ergothioneine transporter), member 4; Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET) | 0.755 |
| ATP5A1 | STYK1 | ENSP00000282050 | ENSP00000075503 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of [...] | serine/threonine/tyrosine kinase 1; Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3’-kinases (PI3K) pathways (By similarity) | 0.815 |
| AVEN | APAF1 | ENSP00000306822 | ENSP00000448165 | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | apoptotic peptidase activating factor 1 | 0.786 |
| AVEN | ATP5A1 | ENSP00000306822 | ENSP00000282050 | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of [...] | 0.813 |
| AVEN | BCL2L1 | ENSP00000306822 | ENSP00000302564 | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis | 0.839 |
| AVEN | GPR83 | ENSP00000306822 | ENSP00000243673 | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | G protein-coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor | 0.875 |
| AVEN | HELT | ENSP00000306822 | ENSP00000343464 | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | helt bHLH transcription factor; Transcriptional repressor which binds preferentially to the canonical E box sequence 5’-CACGCG-3’ (By similarity) | 0.870 |
| AVEN | MEST | ENSP00000306822 | ENSP00000223215 | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | mesoderm specific transcript homolog (mouse) | 0.870 |
| AVEN | OVGP1 | ENSP00000306822 | ENSP00000358747 | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | oviductal glycoprotein 1, 120kDa; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development | 0.814 |
| AVEN | SELV | ENSP00000306822 | ENSP00000333956 | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | selenoprotein V ; May be involved in a redox-related process (Potential) | 0.909 |
| AVEN | SLC22A4 | ENSP00000306822 | ENSP00000200652 | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | solute carrier family 22 (organic cation/ergothioneine transporter), member 4; Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET) | 0.811 |
| AVEN | STYK1 | ENSP00000306822 | ENSP00000075503 | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | serine/threonine/tyrosine kinase 1; Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3’-kinases (PI3K) pathways (By similarity) | 0.824 |
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