node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKR1B10 | GALM | ENSP00000352584 | ENSP00000272252 | aldo-keto reductase family 1, member B10 (aldose reductase); Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs | galactose mutarotase (aldose 1-epimerase); Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) | 0.906 |
AKR1B10 | GLB1 | ENSP00000352584 | ENSP00000306920 | aldo-keto reductase family 1, member B10 (aldose reductase); Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | 0.910 |
AKR1B10 | LCT | ENSP00000352584 | ENSP00000264162 | aldo-keto reductase family 1, member B10 (aldose reductase); Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs | lactase; LPH splits lactose in the small intestine | 0.929 |
B4GALT1 | GLB1 | ENSP00000369055 | ENSP00000306920 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | 0.912 |
B4GALT1 | LCT | ENSP00000369055 | ENSP00000264162 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | lactase; LPH splits lactose in the small intestine | 0.900 |
GALM | AKR1B10 | ENSP00000272252 | ENSP00000352584 | galactose mutarotase (aldose 1-epimerase); Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) | aldo-keto reductase family 1, member B10 (aldose reductase); Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs | 0.906 |
GALM | GLB1 | ENSP00000272252 | ENSP00000306920 | galactose mutarotase (aldose 1-epimerase); Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | 0.920 |
GALM | LCT | ENSP00000272252 | ENSP00000264162 | galactose mutarotase (aldose 1-epimerase); Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) | lactase; LPH splits lactose in the small intestine | 0.920 |
GALNS | GLB1 | ENSP00000268695 | ENSP00000306920 | galactosamine (N-acetyl)-6-sulfate sulfatase | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | 0.980 |
GALNS | GNS | ENSP00000268695 | ENSP00000258145 | galactosamine (N-acetyl)-6-sulfate sulfatase | glucosamine (N-acetyl)-6-sulfatase | 0.447 |
GLB1 | AKR1B10 | ENSP00000306920 | ENSP00000352584 | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | aldo-keto reductase family 1, member B10 (aldose reductase); Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs | 0.910 |
GLB1 | B4GALT1 | ENSP00000306920 | ENSP00000369055 | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 0.912 |
GLB1 | GALM | ENSP00000306920 | ENSP00000272252 | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | galactose mutarotase (aldose 1-epimerase); Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) | 0.920 |
GLB1 | GALNS | ENSP00000306920 | ENSP00000268695 | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | galactosamine (N-acetyl)-6-sulfate sulfatase | 0.980 |
GLB1 | GM2A | ENSP00000306920 | ENSP00000349687 | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | GM2 ganglioside activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 | 0.915 |
GLB1 | GNS | ENSP00000306920 | ENSP00000258145 | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | glucosamine (N-acetyl)-6-sulfatase | 0.913 |
GLB1 | GUSB | ENSP00000306920 | ENSP00000302728 | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | glucuronidase, beta; Plays an important role in the degradation of dermatan and keratan sulfates | 0.968 |
GLB1 | HEXA | ENSP00000306920 | ENSP00000268097 | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | hexosaminidase A (alpha polypeptide); Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity | 0.956 |
GLB1 | HEXB | ENSP00000306920 | ENSP00000261416 | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | hexosaminidase B (beta polypeptide); Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues | 0.959 |
GLB1 | LCT | ENSP00000306920 | ENSP00000264162 | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | lactase; LPH splits lactose in the small intestine | 0.953 |