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C5orf38 C5orf38 KCND2 KCND2 GBX2 GBX2 KCND3 KCND3 APPL1 APPL1 IRX2 IRX2 LBX1 LBX1 TBC1D1 TBC1D1 MNX1 MNX1 AKAP11 AKAP11 KCND1 KCND1
"IRX2" - iroquois homeobox 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
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Cooccurence
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[Homology]
Score
IRX2iroquois homeobox 2 (471 aa)    
Predicted Functional Partners:
C5orf38
chromosome 5 open reading frame 38 (138 aa)
            score_image   0.860
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (630 aa)
            score_image   0.847
KCND3
potassium voltage-gated channel, Shal-related subfamily, member 3; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (655 aa)
            score_image   0.705
AKAP11
A kinase (PRKA) anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them (1901 aa)
            score_image   0.683
MNX1
motor neuron and pancreas homeobox 1; Putative transcription factor involved in pancreas development and function (401 aa)
        score_image   score_image   0.659
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (647 aa)
            score_image   0.638
APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction (709 aa)
            score_image   0.584
LBX1
ladybird homeobox 1; Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord (By similarity) (281 aa)
            score_image   0.577
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) (1168 aa)
            score_image   0.563
GBX2
gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo (348 aa)
        score_image   score_image   0.539
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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