node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKAP11 | IRX2 | ENSP00000025301 | ENSP00000307006 | A kinase (PRKA) anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them | iroquois homeobox 2 | 0.683 |
AKAP11 | TBC1D1 | ENSP00000025301 | ENSP00000261439 | A kinase (PRKA) anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) | 0.680 |
APPL1 | IRX2 | ENSP00000288266 | ENSP00000307006 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction | iroquois homeobox 2 | 0.584 |
C5orf38 | IRX2 | ENSP00000334267 | ENSP00000307006 | chromosome 5 open reading frame 38 | iroquois homeobox 2 | 0.860 |
GBX2 | IRX2 | ENSP00000302251 | ENSP00000307006 | gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo | iroquois homeobox 2 | 0.539 |
IRX2 | AKAP11 | ENSP00000307006 | ENSP00000025301 | iroquois homeobox 2 | A kinase (PRKA) anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them | 0.683 |
IRX2 | APPL1 | ENSP00000307006 | ENSP00000288266 | iroquois homeobox 2 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction | 0.584 |
IRX2 | C5orf38 | ENSP00000307006 | ENSP00000334267 | iroquois homeobox 2 | chromosome 5 open reading frame 38 | 0.860 |
IRX2 | GBX2 | ENSP00000307006 | ENSP00000302251 | iroquois homeobox 2 | gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo | 0.539 |
IRX2 | KCND1 | ENSP00000307006 | ENSP00000218176 | iroquois homeobox 2 | potassium voltage-gated channel, Shal-related subfamily, member 1; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits | 0.638 |
IRX2 | KCND2 | ENSP00000307006 | ENSP00000333496 | iroquois homeobox 2 | potassium voltage-gated channel, Shal-related subfamily, member 2; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits | 0.847 |
IRX2 | KCND3 | ENSP00000307006 | ENSP00000319591 | iroquois homeobox 2 | potassium voltage-gated channel, Shal-related subfamily, member 3; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits | 0.705 |
IRX2 | LBX1 | ENSP00000307006 | ENSP00000359212 | iroquois homeobox 2 | ladybird homeobox 1; Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord (By similarity) | 0.577 |
IRX2 | MNX1 | ENSP00000307006 | ENSP00000252971 | iroquois homeobox 2 | motor neuron and pancreas homeobox 1; Putative transcription factor involved in pancreas development and function | 0.659 |
IRX2 | TBC1D1 | ENSP00000307006 | ENSP00000261439 | iroquois homeobox 2 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) | 0.563 |
KCND1 | IRX2 | ENSP00000218176 | ENSP00000307006 | potassium voltage-gated channel, Shal-related subfamily, member 1; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits | iroquois homeobox 2 | 0.638 |
KCND2 | IRX2 | ENSP00000333496 | ENSP00000307006 | potassium voltage-gated channel, Shal-related subfamily, member 2; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits | iroquois homeobox 2 | 0.847 |
KCND2 | KCND3 | ENSP00000333496 | ENSP00000319591 | potassium voltage-gated channel, Shal-related subfamily, member 2; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits | potassium voltage-gated channel, Shal-related subfamily, member 3; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits | 0.901 |
KCND3 | IRX2 | ENSP00000319591 | ENSP00000307006 | potassium voltage-gated channel, Shal-related subfamily, member 3; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits | iroquois homeobox 2 | 0.705 |
KCND3 | KCND2 | ENSP00000319591 | ENSP00000333496 | potassium voltage-gated channel, Shal-related subfamily, member 3; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits | potassium voltage-gated channel, Shal-related subfamily, member 2; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits | 0.901 |